Neuropeptide Y (NPY) is a 36-amino acid neuropeptide that acts as a neurotransmitter in the brain and in the autonomic nervous system. In the autonomic system it is produced mainly by neurons of the sympathetic nervous system and serves as a strong vasoconstrictor and also causes growth of fat tissue. In the brain, it is produced in various locations including the hypothalamus, and is thought to have several functions, including increasing food intake and storage of energy as fat, reducing anxiety and stress, reducing pain perception, affecting the circadian rhythm, reducing voluntary alcohol intake, lowering blood pressure and controlling epileptic seizures.
CAT# | 10-101-91 |
CAS | 90880-35-6 (net) |
Background | Neuropeptide Y (NPY), a peptide with 36-amino acids, acts as a neurotransmitter in the autonomic nervous system (ANS). It is one of the most abundant neuropeptides in the central and peripheral nervous system. In the periphery, NPY is widely distributed in the adrenal medulla, in the sympathetic nerves, platelets, and various cell types within white adipose tissue. NPY in the central nervous systems is found in highest concentration within the brain stem, hypothalamus, and anterior pituitary. In spite of the major improvements and simplifications in peptide synthesis over the last few years, a considerable amount of skill is still involved in development of neuropeptide Y. Neuropeptide Y (NPY) is a potent neurotransmitter in reproductive endocrine functions regulating stress, eating behavior, and metabolism. Considerable progress has been made in understanding the role of NPY and its receptors in various disorders. |
Synonyms/Alias | NPY (human, rat) |
M.F/Formula | C189H285N55O57S |
M.W/Mr. | 4271.74 |
Sequence | H-Tyr-Pro-Ser-Lys-Pro-Asp-Asn-Pro-Gly-Glu-Asp-Ala-Pro-Ala-Glu-Asp-Met-Ala-Arg-Tyr-Tyr-Ser-Ala-Leu-Arg-His-Tyr-Ile-Asn-Leu-Ile-Thr-Arg-Gln-Arg-Tyr-NH2 acetate salt |
Labeling Target | Neuropeptide Y receptor |
Application | Neuropeptide Y (NPY) is one of the most potent neurotransmitters in reproductive endocrine functions and endocrine functions regulating stress, metabolism and eating behavior. |
Activity | Agonist |
Areas of Interest | Neurological diseases |
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