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MEN 11270 is a peptide antagonist of the B2 bradykinin receptor (pKi = 10.3) and conformationally constrained cyclized analog of HOE 140 (Cat. No. 3014). It can blocks hypotension and bronchoconstriction in vivo.
CAT No: R0807
CAS No: 235082-52-7
Synonyms/Alias: MEN 11270;235082-52-7;MEN-11270;KJA08252;H-D-Arg-Arg-Pro-Hyp-Gly-Thi-c(Dab-DTic-Oic-Arg)c(7gamma-10alpha);AKOS024457909;PD079706;
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M.F/Formula | C60H90N20O11S |
M.W/Mr. | 1299.6 |
Sequence | Three Letter Code:H-D-Arg-Arg-Pro-Hyp-Gly-D-2Thi-Dab(1)-D-Tic-Oic(3axi,7axi)-Arg-(1) |
Labeling Target | B2 bradykinin receptor |
Appearance | White lyophilised solid |
Activity | Antagonist |
InChI | InChI=1S/C60H90N20O11S/c61-38(14-5-20-69-58(62)63)49(83)75-40(16-7-22-71-60(66)67)54(88)77-24-8-18-44(77)56(90)79-32-36(81)28-45(79)52(86)72-30-48(82)73-42(29-37-13-9-25-92-37)51(85)76-41-19-23-68-50(84)39(15-6-21-70-59(64)65)74-53(87)46-27-34-11-3-4-17-43(34)80(46)57(91)47-26-33-10-1-2-12-35(33)31-78(47)55(41)89/h1-2,9-10,12-13,25,34,36,38-47,81H,3-8,11,14-24,26-32,61H2,(H,68,84)(H,72,86)(H,73,82)(H,74,87)(H,75,83)(H,76,85)(H4,62,63,69)(H4,64,65,70)(H4,66,67,71)/t34?,36-,38-,39+,40+,41+,42-,43?,44+,45+,46+,47-/m1/s1 |
InChI Key | LPLBKEKLEUYDEJ-UUHVOKIZSA-N |
Isomeric SMILES | C1CC[C@H]2[C@@H](C1)C[C@@H]3N2C(=O)[C@H]4CC5=CC=CC=C5CN4C(=O)[C@H](CCNC(=O)[C@@H](NC3=O)CCCN=C(N)N)NC(=O)[C@H](CC6=CC=CS6)NC(=O)CNC(=O)[C@@H]7C[C@H](CN7C(=O)[C@@H]8CCCN8C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](CCCN=C(N)N)N)O |
BoilingPoint | N/A |
Melting Point | N/A |
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