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This is a 21 amino acid peptide derived from Buforin I peptide that is isolated from the Asian toad Bufo gargarizans,also referred to as Buforin II. It has been shown to possess anti-microbial activity by penetrating bacteria and inhibiting cellular functions. In comparison to magainin 2, this peptide binds DNA and RNA from E.coli with a much greater affinity. It is also considered a cell-delivery peptide and has been shown to deliver SiRNAs into cells followed by effective mRNA degradation.
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M.W/Mr. | 2434.9 |
Sequence | H-Thr-Arg-Ser-Ser-Arg-Ala-Gly-Leu-Gln-Phe-Pro-Val-Gly-Arg-Val-His-Arg-Leu-Leu-Arg-Lys-OH |
Long-term Storage Conditions | Soluble in pure water. Avoid repeated freezing and thawing. |
3. Autoinhibition and phosphorylation-induced activation of phospholipase C-γ isozymes
4. Myotropic activity of allatostatins in tenebrionid beetles
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