Atosiban, also known as ORF 22164, RWJ 22164, is an inhibitor of the hormones oxytocin and vasopressin. It is used as an intravenous medication as a labour repressant (tocolytic) to halt premature labor. Although initial studies suggested it could be used as a nasal spray and hence would not require hospital admission, it is not used in that form.
CAT# | R1968 |
Chemical Structure | |
CAS | 914453-95-5 |
Synonyms/Alias | ORF-22164; ORF 22164; ORF22164; RWJ-22164; RWJ 22164; RWJ22164; Atosiban. trade names Tractocile, Antocin, atosiban SUN; deamino-cysteinyl-O4-ethyl-D-tyrosyl-L-isoleucyl-L-threonyl-L-asparagyl-L-cysteinyl-L-prolyl-L-ornithyl-glycinamide (1->6)-disulfide acetic acid |
Chemical Formula | acetic acid;(2S)-N-[(2S)-5-amino-1-[(2-amino-2-oxoethyl)amino]-1-oxopentan-2-yl]-1-[(4R,7S,10S,13S,16R)-7-(2-amino-2-oxoethyl)-13-[(2S)-butan-2-yl]-16-[(4-ethoxyphenyl)methyl]-10-[(1R)-1-hydroxyethyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]pyrrolidine-2-carboxamide |
M.F/Formula | C45H71N11O14S2 |
M.W/Mr. | 1054.2 |
Sequence | One Letter Code: CXITNCPXG Three Letter Code: deamino-Cys(1)-D-Tyr(Et)-Ile-Thr-Asn-Cys(1)-Pro-Orn-Gly-NH2.CH3CO2H |
Appearance | Solid powder |
Activity | Agonist |
Target | Oxytocin Receptor |
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