AC 187

Potent and selective amylin receptor antagonist that displays 38-fold and 400-fold selectivity over calcitonin and CGRP receptors respectively. Through attenuating the activation of initiator and effector caspases in vitro, it blocks amyloid β-induced neurotoxicity. It can increase glucagon secretion, accelerate gastric emptying, change plasma glucose levels and increase food intake in vivo.

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CAT#R0952
CAS151804-77-2
M.F/FormulaC127H205N37O40
M.W/Mr.2890.25
SequenceAc-VLGKLSQELHKLQTYPRTNTGSNTY-NH2
Labeling TargetAmylin receptor
ApplicationBlocks amyloid β-induced neurotoxicity by attenuating the activation of initiator and effector caspases in vitro. Increases glucagon secretion, accelerates gastric emptying, alters plasma glucose levels and increases food intake in vivo.
AppearanceWhite lyophilised solid
Purity>98%
ActivityAntagonist
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