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Z-VRPR-FMK trifluoroacetate salt

A selective, irreversible and cell permeable MALT1 inhibitor. Suppresses T cell activation-induced cleavage of Bcl-10 in a dose-dependent manor. Reduces Jurkat cell adhesion to fibronectin.

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CAT#	R1085
Synonyms/Alias	Z-Val-Arg-Pro-DL-Arg-FMK
M.F/Formula	C31H49FN10O6.CF3CO2H
M.W/Mr.	790.81
Sequence	Z-VRPR-FMK
Labeling Target	MALT1
Appearance	Solid powder
Purity	>90%
Activity	Inhibitor

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Storage	-20°C
InChI	InChI=1S/C31H49FN10O6.C2HF3O2/c1-19(2)25(41-31(47)48-18-20-9-4-3-5-10-20)27(45)40-22(12-7-15-38-30(35)36)28(46)42-16-8-13-23(42)26(44)39-21(24(43)17-32)11-6-14-37-29(33)34;3-2(4,5)1(6)7/h3-5,9-10,19,21-23,25H,6-8,11-18H2,1-2H3,(H,39,44)(H,40,45)(H,41,47)(H4,33,34,37)(H4,35,36,38);(H,6,7)/t21?,22-,23-,25-;/m0./s1
InChI Key	WIPHXOQUHDJLCU-WTJMUODPSA-N
Isomeric SMILES	CC(C)[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)NC(CCCN=C(N)N)C(=O)CF)NC(=O)OCC2=CC=CC=C2.C(=O)(C(F)(F)F)O