SN50

SN50

SN50, also named NF-KB inhibitor, is a synthetic peptide corresponding to the nuclear localization sequence of NF-KB p105 subunit (also known as p50) appended to a hydrophobic sequence to facilitate import into living cells. It blocks the nuclear import of p105 in cells treated with activators of NF-KB signaling, including LPS and TNF-Alpha.

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CAT No: R1845

CAS No: 213546-53-3

Synonyms/Alias: SN50;213546-53-3;NFkappaB Inhibitor;NF-kappaB Inhibitor, SN50;H-ALA-ALA-VAL-ALA-LEU-LEU-PRO-ALA-VAL-LEU-LEU-ALA-LEU-LEU-ALA-PRO-VAL-GLN-ARG-LYS-ARG-GLN-LYS-LEU-MET-PRO-OH;NF-kappaB SN50;SN50 trifluoroacetate salt;AAVALLPAVLLALLAPVQRKRQKLMP;CHEBI:195371;SN 50;SN-50;H-AAVALLPAVLLALLAPVQRKRQKLMP-OH;AKOS040738511;DA-57948;FN109704;G12952;Nuclear Factor NF-KB Inhibitor SN50 trifluoroacetate salt;H-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Val-Gln- Arg-Lys-Arg-Gln-Lys-Leu-Met-Pro-OH; H-AAVALLPAVLLALLAPVQR KRQKLMP-OH;L-Ala-L-Ala-L-Val-L-Ala-L-Leu-L-Leu-L-Pro-L-Ala-L-Val-L-Leu-L-Leu-L-Ala-L-Leu-L-Leu-L-Ala-L-Pro-L-Val-L-Gln-L-Arg-L-Lys-L-Arg-L-Gln-L-Lys-L-Leu-L-Met-L-Pro;L-alanyl-L-alanyl-L-valyl-L-alanyl-L-leucyl-L-leucyl-L-prolyl-L-alanyl-L-valyl-L-leucyl-L-leucyl-L-alanyl-L-leucyl-L-leucyl-L-alanyl-L-prolyl-L-valyl-L-glutaminyl-L-arginyl-L-lysyl-L-arginyl-L-glutaminyl-L-lysyl-L-leucyl-L-methionyl-L-proline;

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M.F/Formula	C129H230N36O29S
M.W/Mr.	2781.5
Sequence	One Letter Code:AAVALLPAVLLALLAPVQRKRQKLMP Three Letter Code:H-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Val-Gln-Arg-Lys-Arg-Gln-Lys-Leu-Met-Pro-OH
Application	This peptide is commonly used to evaluate the role of NF-KB signaling in cellular responses.
Appearance	Lyophilized solid
Purity	≥97% by HPLC

Shipping Condition	Gel Pack
InChI	InChI=1S/C129H230N36O29S/c1-64(2)57-87(156-117(183)92(62-69(11)12)158-123(189)100(72(17)18)161-106(172)78(25)143-119(185)94-41-35-54-164(94)126(192)93(63-70(13)14)159-118(184)90(60-67(7)8)154-104(170)76(23)144-121(187)99(71(15)16)160-105(171)77(24)141-102(168)74(21)132)113(179)142-75(22)103(169)153-89(59-66(5)6)116(182)157-88(58-65(3)4)114(180)145-79(26)124(190)163-53-34-42-95(163)120(186)162-101(73(19)20)122(188)151-85(45-47-98(134)167)112(178)149-82(39-32-51-139-128(135)136)108(174)146-80(37-28-30-49-130)107(173)148-83(40-33-52-140-129(137)138)109(175)150-84(44-46-97(133)166)111(177)147-81(38-29-31-50-131)110(176)155-91(61-68(9)10)115(181)152-86(48-56-195-27)125(191)165-55-36-43-96(165)127(193)194/h64-96,99-101H,28-63,130-132H2,1-27H3,(H2,133,166)(H2,134,167)(H,141,168)(H,142,179)(H,143,185)(H,144,187)(H,145,180)(H,146,174)(H,147,177)(H,148,173)(H,149,178)(H,150,175)(H,151,188)(H,152,181)(H,153,169)(H,154,170)(H,155,176)(H,156,183)(H,157,182)(H,158,189)(H,159,184)(H,160,171)(H,161,172)(H,162,186)(H,193,194)(H4,135,136,139)(H4,137,138,140)/t74-,75-,76-,77-,78-,79-,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,99-,100-,101-/m0/s1
InChI Key	FAWLNURBQMTKEB-URDPEVQOSA-N
Canonical SMILES	CC(C)CC(C(=O)NC(CC(C)C)C(=O)NC(C)C(=O)N1CCCC1C(=O)NC(C(C)C)C(=O)NC(CCC(=O)N)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCCN)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCC(=O)N)C(=O)NC(CCCCN)C(=O)NC(CC(C)C)C(=O)NC(CCSC)C(=O)N2CCCC2C(=O)O)NC(=O)C(C)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(C(C)C)NC(=O)C(C)NC(=O)C3CCCN3C(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(C(C)C)NC(=O)C(C)NC(=O)C(C)N

1. Spatiotemporal delivery of nanoformulated liraglutide for cardiac regeneration after myocardial infarction

2. P-selectin and Complement’s Role in a Neonatal Model of Germinal Matrix Hemorrhage-Induced Secondary Injury

3. Therapeutic potential of an intestinotrophic hormone, glucagon-like peptide 2, for treatment of type 2 short bowel syndrome rats with intestinal bacterial and fungal dysbiosis

4. The spatiotemporal control of signalling and trafficking of the GLP-1R

5. Cationic cell-penetrating peptides are potent furin inhibitors

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