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This peptide is a poly-gamma-D-glutamic acid (DPGA)10 construct that relates to the sequence of the Bacillus anthracis capsule which is composed of gamma DPGA. gamma DPGA is an essential virulence factor of B. anthracis. The capsule inhibits innate host defense through its antiphagocytic action. gamma DPGA is a poor immunogen, but when bound to a carrier protein, it elicits serum antibodies.
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M.W/Mr. | 2099 |
Sequence | One Letter Code: Ac-(γ-e)15-C-NH2 Three Letter Code: Ac-(γ-D-Glu)15-Cys-NH2 |
References | Kubler-Kielb, J. et al. Infect. Immun. 74, 4744 (2006). |
2. Myotropic activity of allatostatins in tenebrionid beetles
3. Cell-based adhesion assays for isolation of snake venom’s integrin antagonists
4. TMEM16F and dynamins control expansive plasma membrane reservoirs
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