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Selective antagonist of α3β2 nAChR receptors
CAT No: R1006
CAS No: 705300-84-1
Synonyms/Alias: alpha-conotoxin PnIA;705300-84-1;A-CONOTOXIN PNIA;CHEMBL4443205;alpha-Conotoxin PnIA TFA;GTPL3982;BDBM50516319;AKOS024457442;DA-79161;Q27074398;S-705300-84-1;
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M.F/Formula | C65H95N19O22S4 |
M.W/Mr. | 1622.8 |
Sequence | One Letter Code:GCCSLPPCAANNPDYC Three Letter Code:H-Gly-Cys(1)-Cys(2)-Ser-Leu-Pro-Pro-Cys(1)-Ala-Ala-Asn-Asn-Pro-Asp-Tyr-Cys(2)-NH2 |
Labeling Target | α3β2 nAChR receptors |
Appearance | White lyophilised solid |
Purity | >97% |
Activity | Antagonist |
InChI | InChI=1S/C65H95N19O22S4/c1-29(2)18-37-63(104)84-17-7-10-46(84)65(106)83-16-6-9-45(83)62(103)81-42-27-110-108-26-41(72-49(89)23-66)59(100)80-43(60(101)78-39(24-85)57(98)76-37)28-109-107-25-40(51(69)92)79-54(95)34(19-32-11-13-33(86)14-12-32)74-56(97)36(22-50(90)91)75-61(102)44-8-5-15-82(44)64(105)38(21-48(68)88)77-55(96)35(20-47(67)87)73-53(94)31(4)70-52(93)30(3)71-58(42)99/h11-14,29-31,34-46,85-86H,5-10,15-28,66H2,1-4H3,(H2,67,87)(H2,68,88)(H2,69,92)(H,70,93)(H,71,99)(H,72,89)(H,73,94)(H,74,97)(H,75,102)(H,76,98)(H,77,96)(H,78,101)(H,79,95)(H,80,100)(H,81,103)(H,90,91)/t30-,31-,34-,35-,36-,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-/m0/s1 |
InChI Key | VUVGEYBNLLGGBG-MVPSLEAZSA-N |
Isomeric SMILES | C[C@H]1C(=O)N[C@H](C(=O)N[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CSSC[C@H]3C(=O)N[C@H](C(=O)N[C@H](C(=O)N4CCC[C@H]4C(=O)N5CCC[C@H]5C(=O)N[C@@H](CSSC[C@@H](C(=O)N3)NC(=O)CN)C(=O)N[C@H](C(=O)N1)C)CC(C)C)CO)C(=O)N)CC6=CC=C(C=C6)O)CC(=O)O)CC(=O)N)CC(=O)N |
BoilingPoint | N/A |
Melting Point | N/A |
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