Biotin-LC-Angiotensin II
This octapeptide Angiotensin II, DRVYIHPF, is biotinylated on the N-terminus via an LC (long chain, also known as 6-Aminohexanoyl, 6-Aminocaproyl or Ahx) linker. It can be used in ELISA assay. Angiotensin II (Ang II) exerts a wide range of effects on the cardiovascular system. It is also implicated in the regulation of cell proliferation, fibrosis and apoptosis. Ang II is formed by cleavage of Ang I by the angiotensin-converting enzyme (ACE) or chymases. Human heart chymase, a chymotrypsin-like serine proteinase, hydrolyzes the Phe8-His9 bond to yield the octapeptide hormone angiotensin II and His-Leu.
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| CAT# | A15119 |
| M.W/Mr. | 1385.7 |
| Sequence | One Letter Code: Biotin-LC-DRVYIHPF
Three Letter Code: Biotin-LC-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-OH |
| Storage | -20°C |
References | 1, Cobb, C. et al. Gen Comp Endocrinol 127, 8 (2002)
2, Lundequist, A. et al. J Biol Chem 279, 32339 (2004)
3, Kinoshita, A. et al. J Biol Chem 266, 19192 (1991)
4, Spyroulias, G. et al. Eur J Biochem 270, 2163 (2003). |
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