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BIM 23056

BIM 23056 behaves as a potent and selective antagonist of somatostatin receptor 5.

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CAT No: R0827

CAS No: 150155-61-6

Synonyms/Alias: 150155-61-6;BIM 23056;D-Alaninamide, D-phenylalanyl-L-phenylalanyl-L-tyrosyl-D-tryptophyl-L-lysyl-L-valyl-L-phenylalanyl-3-(2-naphthalenyl)-;(2S)-6-Amino-N-[(2S)-1-[[(2S)-1-[[(2R)-1-amino-3-naphthalen-2-yl-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]hexanamide;FFYWKVFA;D-Phe-Phe-Tyr-D-Trp-Lys-Val-Phe-D-Nal-NH2;CHEMBL410596;SCHEMBL12912367;BDBM82256;BIM23056;AKOS024456811;DA-61666;DC-25-20;PD079144;CAS_150155-61-6;G12888;(2S)-6-AMINO-2-[(2R)-2-[(2S)-2-[(2S)-2-[(2R)-2-AMINO-3-PHENYLPROPANAMIDO]-3-PHENYLPROPANAMIDO]-3-(4-HYDROXYPHENYL)PROPANAMIDO]-3-(1H-INDOL-3-YL)PROPANAMIDO]-N-[(1S)-1-{[(1S)-1-{[(1R)-1-CARBAMOYL-2-(NAPHTHALEN-2-YL)ETHYL]CARBAMOYL}-2-PHENYLETHYL]CARBAMOYL}-2-METHYLPROPYL]HEXANAMIDE;D-Alaninamide,D-phenylalanyl-L-phenylalanyl-L-tyrosyl-D-tryptophyl-L-lysyl-L-valyl-L-phenylalanyl-3-(2-naphthalenyl)-;

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M.F/FormulaC71H81N11O9
M.W/Mr.1232.5
SequenceOne Letter Code:FFYWKVFX
Three Letter Code:H-D-Phe-Phe-Tyr-D-Trp-Lys-Val-Phe-D-2Nal-NH2
Labeling TargetSomatostatin receptor 5 (sst5)
AppearanceWhite lyophilised solid
Purity>98 %
ActivityAntagonist
Source#Synthetic
Solubility-20 °C
InChIInChI=1S/C71H81N11O9/c1-44(2)63(71(91)81-61(39-47-22-10-5-11-23-47)67(87)77-58(64(74)84)41-49-29-32-50-24-12-13-25-51(50)36-49)82-66(86)57(28-16-17-35-72)76-70(90)62(42-52-43-75-56-27-15-14-26-54(52)56)80-69(89)60(40-48-30-33-53(83)34-31-48)79-68(88)59(38-46-20-8-4-9-21-46)78-65(85)55(73)37-45-18-6-3-7-19-45/h3-15,18-27,29-34,36,43-44,55,57-63,75,83H,16-17,28,35,37-42,72-73H2,1-2H3,(H2,74,84)(H,76,90)(H,77,87)(H,78,85)(H,79,88)(H,80,89)(H,81,91)(H,82,86)/t55-,57+,58-,59+,60+,61+,62-,63+/m1/s1
InChI KeyVPTPBEUWKCLZGU-OOSWLFMASA-N
Isomeric SMILESCC(C)[C@@H](C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@H](CC2=CC3=CC=CC=C3C=C2)C(=O)N)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC4=CNC5=CC=CC=C54)NC(=O)[C@H](CC6=CC=C(C=C6)O)NC(=O)[C@H](CC7=CC=CC=C7)NC(=O)[C@@H](CC8=CC=CC=C8)N
BoilingPointN/A
Melting PointN/A
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    Glucagon-like peptide-1 (GLP-1) is an incretin derived from the transcription product of the proglucagon gene. The major source of GLP-1 in the body is the intestinal L cell that secretes GLP-1 as a gut hormone. Its physiological functions include promoting insulin sensitivity, decreasing food intake by increasing satiety in brain and increasing insulin secretion from the pancreas in a glucose-dependent manner.

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