Bacterial Sortase Substrate I, FRET

This 5-amino acid peptide is a sortase substrate, C-terminal sorting signal. Sortase cleaves surface proteins at the LPXTG motif and catalyzes the formation of an amide bond between the carboxyl group of threonine and the amino group of cell-wall crossbridges. Sortases are a family of Gram-positive transpeptidases responsible for anchoring surface protein virulence factors to the peptidoglycan cell wall layer. Cleavage of this FRET substrate by sortase reveals the fluorescent signal, Abs/Em = 340/490 nm.

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CAT#	B01035
M.W/Mr.	1015.2
Sequence	Three-Letter Code: DABCYL-Leu-Pro-Glu-Thr-Gly-EDANS One-Letter Code: DABCYL-LPETG-EDANS

CAT#	Product Name	Inquiry
B01039	SPase I FRET Substrate	Inquiry
B01027	N-10 Region of TRAP	Inquiry
B01036	Bacterial Sortase Substrate II Dabcyl/Edans	Inquiry
B01016	CRGKA, Giardia Variable Surface Proteins Conserved Region	Inquiry
B01030	P62 (417-429), M. leprae	Inquiry

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Storage	-20°C
References	Mazmanian, S. et al. PNAS 99, 2293 (2002); Ilangovan, U. et al. PNAS 98, 6056 (2001), Ton-That, H. et al. PNAS 96, 12424 (1999); W. Navarre and O. Schneewind Microbiol. Mol. Biol. Rev. 63, 174 (1999).