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SHLP6 (Small humanin-like peptide 6)

Recent advances in high-resolution sequencing have led to the discovery of unique peptides derived from mitochondrial genome.1-2Currently 8 peptides are identified: humanin, mitochondrial open reading frame of the 12S tRNA-c (MOTS-c), and six small humanin-like peptides (SHLP1-6). 1-2All of these peptides are released into cytosol from mitochondria. SHLP6 has been shown to increase apoptosis with potential cancer targeting roles and also may be involved in aging.1-2

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M.W/Mr.2385.9
SequenceOne Letter Code: H-MLDQDIPMVQPLLKVRLFND-OH
Three Letter Code: NH2-Met-Leu-Asp-Gln-Asp-Ile-Pro-Met-Val-Gln-Pro-Leu-Leu-Lys-Val-Arg-Leu-Phe-Asn-Asp-COOH
References1. Cobb L. J. et al., AGING 8 (4), 796-808 (2016).
2. Okada A. K. et al., Sci Reports 7 (7802), 1-10 (2017). .
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