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Recent advances in high-resolution sequencing have led to the discovery of unique peptides derived from mitochondrial genome.1-2Currently 8 peptides are identified: humanin, mitochondrial open reading frame of the 12S tRNA-c (MOTS-c), and six small humanin-like peptides (SHLP1-6). 1-2All of these peptides are released into cytosol from mitochondria. SHLP6 has been shown to increase apoptosis with potential cancer targeting roles and also may be involved in aging.1-2
Peptide Library Construction and Screening
Powerful screening tools in biological and chemical research
M.W/Mr. | 2385.9 |
Sequence | One Letter Code: H-MLDQDIPMVQPLLKVRLFND-OH Three Letter Code: NH2-Met-Leu-Asp-Gln-Asp-Ile-Pro-Met-Val-Gln-Pro-Leu-Leu-Lys-Val-Arg-Leu-Phe-Asn-Asp-COOH |
References | 1. Cobb L. J. et al., AGING 8 (4), 796-808 (2016). 2. Okada A. K. et al., Sci Reports 7 (7802), 1-10 (2017). . |
1. Cationic cell-penetrating peptides are potent furin inhibitors
2. SERS spectrum of the peptide thymosin‐β4 obtained with Ag nanorod substrate
3. Emu oil in combination with other active ingredients for treating skin imperfections
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