Norleual

Norleual is an angiotensin (Ang) IV analog, and acts as highly potent HGF/c-MET inhibitor (IC50 = 3 pM) that inhibits HGF-induced MDCK cell proliferation and invasion in vitro. It also is AT4 receptor antagonist, disrupts LTP stabilization. It shows antiangiogenic activity.

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CAT#R1054
CAS334994-34-2
Background

The angiotensin (Ang) IV analog norleual [Nle-Tyr-Leu-ψ-(CH2-NH2)3-4-His-Pro-Phe] exhibits structural homology with the hinge (linker) region of hepatocyte growth factor (HGF) and is hypothesized to act as a hinge region mimic. Norleual competitively inhibited the binding of HGF to its receptor c-Met in mouse liver membranes, with an IC50 value of 3 pM.   >> Read More

Synonyms/AliasL-Norleucyl-L-tyrosyl-L-leucyl-ψ(ch2-nh)-L-histidyl-L-prolyl-L-phenylalanine
M.F/FormulaC41H58N8O7
M.W/Mr.774.95
SequenceXYLHPF(Modifications: X = Nle, Leu-3-His-4 peptide bond replaced with CH2NH)
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