Natamycin

Natamycin is a polyene amphoteric macrolide antibiotic with antifungal properties. Natamycin exerts its antifungal effects by binding to sterols in the fungal cell membrane thereby increasing membrane permeability. This leads to a leakage and loss of essential cellular constituents. Following ocular application, natamycin is retained in the conjunctival fornices and attains effective concentrations within the corneal stroma where it exerts its effect.

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CAT#Z10-101-166
CAS7681-93-8
Synonyms/AliasPimaricin;Tennecetin; Myprozine;
M.F/FormulaC33H47NO13
M.W/Mr.665.73
Labeling Target30s ribosomal subunit
ApplicationNatamycin is an antifungal drug for topical ophthalmic administration. It is a tetraene polyene antibiotic derived from Streptomyces natalensis. It possesses in vitro activity against a variety of yeast and filamentous fungi, including Candida, Aspergillus, Cephalosporium, Fusarium and Penicillium. Although the activity against fungi is dose-related, natamycin is predominantly fungicidal. Natamycin is not effective in vitro against gram-positive or gram-negative bacteria. Topical administration appears to produce effective concentrations of natamycin within the corneal stroma but not in intraocular fluid.
AppearanceSolid powder
Purity>98% (or refer to the Certificate of Analysis)
Biological ActivityNatamycin (Pimaricin) is a macrolide antibiotic agent produced by several Streptomyces strains. Natamycin inhibits the growth of fungi via inhibition of amino acid and glucose transport across the plasma membrane.
Areas of InterestImmunology & Inflammation
Cell Biology
Cancer
FunctionsNatamycin is used for a variety of fungal infections, mainly topically.
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