We use cookies to understand how you use our site and to improve the overall user experience. This includes personalizing content and advertising. Read our Privacy Policy
Compstatin is a 13-residue cyclic peptide that inhibits complement activation by binding to complement component C3. It acts as a potent inhibitor of the complement system.
Peptide Library Construction and Screening
Powerful screening tools in biological and chemical research
M.F/Formula | C66H99N23O17S2 |
M.W/Mr. | 1550.77 |
Sequence | One Letter Code: ICVVQDWGHHRCT-NH2 (Disulfide bridge: Cys2-Cys12) Three Letter Code: Ile-Cys-Val-Val-Gln-Asp-Trp-Gly-His-His-Arg-Cys-Thr-NH2 (Disulfide bridge: Cys2-Cys12) |
Biological Activity | Complement inhibitor; binds C3 inhibiting proteolytic cleavage by C3 convertase (IC50 = 28 μM) and activation of classical and alternative complement pathways (IC50 values are 63 and 12 μM respectively). Prolongs graft survival and reduces hyperacute rejection of ex vivo pig kidneys perfused with human blood and inhibits in vivo heparin/protamine-induced complement activation in primates. |
Long-term Storage Conditions | Soluble to 2 mg/ml in water |
Shipping Condition | Room temperature in continental US; may vary elsewhere. |
2. C-Peptide replacement therapy and sensory nerve function in type 1 diabetic neuropathy
4. The spatiotemporal control of signalling and trafficking of the GLP-1R
5. Autoinhibition and phosphorylation-induced activation of phospholipase C-γ isozymes
If you have any peptide synthesis requirement in mind, please do not hesitate to contact us at info@creative-peptides.com. We will endeavor to provide highly satisfying products and services.
USA
Address: SUITE 115, 17 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-624-4882
Fax: 1-631-614-7828
Email: info@creative-peptides.com
Germany
Address: Industriepark Höchst, Gebäude G830
65929 Frankfurt am Main
Email: info@creative-peptides.com