Camstatin

Camstatin is a similar PEP-19 analogue with enhanced calmodulin binding and antagonism. It is a functional 25-residue fragment of the IQ motif of PEP19 that binds to calmodulin and inhibits nitric oxide synthase in neurons. It defines the lowest active domain of PEP-19, and its binding affinity to calmodulin is positively correlated with its role as an inhibitor of nitric oxide synthase.  >> Read More

Camstatin is a synthetic peptide (Pep-4, Table 2) modified from a sequence within PEP-19, a neuronal calmodulin-binding protein of unknown function, which includes the very basic IQ motif (commonly IQXXXRGXXXR) found in several proteins that bind calmodulin in the absence of Ca2+. Camstatin binds with similar affinity to calmodulin and Ca2+–calmodulin.

A novel role for calmodulin: Ca2+-independent inhibition of type-1 inositol trisphosphate receptors