Anisomycin

Anisomycin is an antibiotic isolated from various Streptomyces species. It interferes with protein and DNA synthesis by inhibiting peptidyl transferase or the 80S ribosome system.

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CAT#Z10-101-164
CAS22862-76-6
Background

Anisomycin, also known as flagecidin, is an antibiotic produced by Streptomyces griseolus which inhibits eukaryotic protein synthesis. Partial inhibition of DNA synthesis occurs at anisomycin concentrations that effect 95% inhibition of protein synthesis. Anisomycin can activate stress-activated protein kinases, MAP kinase and other signal transduction pathways. Anisomycin is inactive against bacteria. Anisomycin interferes with protein and DNA synthesis by inhibiting peptidyl transferase or the 80S ribosome system.  >> Read More

Synonyms/AliasFlagecidin
M.F/FormulaC14H19NO4
M.W/Mr.265.31
Labeling Targetc-Jun N-terminal kinase (JNK)
ApplicationAnisomycin is used as a antineoplastic agent that inhibits or prevents the proliferation of neoplasms.
AppearanceSolid powder
Purity>98% (or refer to the Certificate of Analysis)
ActivityInhibitor
Biological ActivityAnisomycin is a potent protein synthesis inhibitor which interferes with protein and DNA synthesis by inhibiting peptidyl transferase or the 80S ribosome system. Anisomycin is a JNK activator, which increases phospho-JNK. Anisomycin is a bacterial antibiotic.
Areas of InterestImmunology & Inflammation
Cell Biology
Cancer
FunctionsAnisomycin is inactive against bacteria.
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