Amylin (20-29) (human)

Amylin (20-29), human forms fibrils that are structurally similar to amyloid fibrils in pancreatic islets. This appears to be the most important amyloidogenic sequence in human amylin. This amino acids 20 to 29 fragment of amylin is critical to the pathogenesis of islet amyloid.

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CAT#	A12020
CAS	118068-30-7
Synonyms/Alias	L-seryl-L-asparagyl-L-asparagyl-L-phenylalanyl-glycyl-L-alanyl-L-isoleucyl-L-leucyl-L-seryl-L-serine
Chemical Name	(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S)-4-amino-2-[[(2S)-2-amino-3-hydroxypropanoyl]amino]-4-oxobutanoyl]amino]-4-oxobutanoyl]amino]-3-phenylpropanoyl]amino]acetyl]amino]propanoyl]amino]-3-methylpentanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxypropanoyl]amino]-3-hydroxypropanoic acid
M.F/Formula	C43H68N12O16
M.W/Mr.	1009.1
Sequence	One Letter Code: SNNFGAILSS Three-Letter Code: H-Ser-Asn-Asn-Phe-Gly-Ala-Ile-Leu-Ser-Ser-OH

CAT#	Product Name	Inquiry
A12004	Amylin(20-29), Islet Amyloid Polypeptide, IAPP (20-29), hamster	Inquiry
A12018	5-FAM-Amylin (mouse, rat)	Inquiry
A12012	Acetyl-Amylin (8-37), rat	Inquiry
A12016	Amylin, rat	Inquiry
A12001	Amylin(20-29), Islet Amyloid Polypeptide, IAPP (20-29), rat	Inquiry

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Storage	Store at -20°C
InChI	InChI=1S/C43H68N12O16/c1-6-21(4)34(42(69)52-25(12-20(2)3)38(65)53-29(18-57)41(68)54-30(19-58)43(70)71)55-35(62)22(5)48-33(61)16-47-37(64)26(13-23-10-8-7-9-11-23)50-40(67)28(15-32(46)60)51-39(66)27(14-31(45)59)49-36(63)24(44)17-56/h7-11,20-22,24-30,34,56-58H,6,12-19,44H2,1-5H3,(H2,45,59)(H2,46,60)(H,47,64)(H,48,61)(H,49,63)(H,50,67)(H,51,66)(H,52,69)(H,53,65)(H,54,68)(H,55,62)(H,70,71)/t21-,22-,24-,25-,26-,27-,28-,29-,30-,34-/m0/s1
InChI Key	RMSCIVKVSZSEHU-ITYUDAQQSA-N
Canonical SMILES	CCC(C)C(C(=O)NC(CC(C)C)C(=O)NC(CO)C(=O)NC(CO)C(=O)O)NC(=O)C(C)NC(=O)CNC(=O)C(CC1=CC=CC=C1)NC(=O)C(CC(=O)N)NC(=O)C(CC(=O)N)NC(=O)C(CO)N
Isomeric SMILES	CC[C@H](C)[C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)O)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CO)N