Lipopeptides Synthesis Service

Lipopeptides are a class of molecules that have been attracting considerable attention recently due to their unique properties and potential applications in various fields. They have a peptide backbone (amino acid chain) and a lipid tail. The lipid tail is typically composed of one or more fatty acid chains that are linked to the peptide backbone through an amide bond. The combination of peptide and lipid components gives lipopeptides their unique properties.

Creative Peptides is a leading peptides synthesis service vendor, so we can offer a fast and high quality synthesis of compounds at a low prices.

Classification of Lipopeptides

Lipopeptides can be classified based on various criteria, including their chemical structure, mode of action, and biological activity. Here are a few common classifications of lipopeptides:

• Cyclic and linear lipopeptides
• Antimicrobial and non-antimicrobial lipopeptides
• Surfactant and non-surfactant lipopeptides
• Biosurfactant and chemical surfactant lipopeptides

Applications of Lipopeptides

Recent literature has shown that lipopeptides help in the study of several biological activities such as cellular uptake, drug delivery, immune function, membrane targeting, localization etc.

• Proper functioning of cellular mechanisms/signal transduction
• Antimicrobial or antifungal properties
• Protein-protein interactions
• Protein-lipid interactions
• Membrane targeting & localization
• Cell permeability

In addition to pharmaceutical research, lipopeptides can also be used in other industries:

• Cosmetic: Lipopeptides have anti-aging properties and can be used in various cosmetic and skincare products. They improve skin elasticity, reduce the appearance of wrinkles and fine lines, and enhance skin hydration.
• Food industry: Lipopeptides can be used as food preservatives and as food additives.
• Bioremediation: Treating contaminated soils and water. They can break down hydrophobic compounds and help to solubilize contaminants, making them easier to remove.

Our Synthesis Technology

Solid-phase peptide synthesis (SPPS)

It involves sequential addition of protected amino acids onto a solid support, followed by deprotection and cleavage to release the peptide. The lipid component is then attached to the peptide using coupling agents such as DCC or EDC.

Solution-phase peptide synthesis

This method involves reacting the protected amino acids and lipid component in solution, followed by purification and deprotection to obtain the final lipopeptide product.

Enzymatic synthesis

Using enzymes such as lipases, which can catalyze the esterification of a fatty acid to a peptide.

Chemical ligation

Synthesizing the peptide and lipid components separately and then using chemical ligation reactions to join them together.

Combination methods

Our Characterization Techniques

• Nuclear magnetic resonance (NMR) spectroscopy
• High-performance liquid chromatography (HPLC)
• Circular dichroism (CD) spectroscopy:
• Mass spectrometry
• Biological assays

Competitive Advantages

• Short lead times
• Valuation in 24 hours
• High purity
• GMP grade available (see GMP Peptides)
• Additional analyses, such as stability determination, amino acid analysis, and residual solvents etc.

Creative Peptides provides efficient and high quality peptide synthesis services while offering different modification services.