Sincalide
Sincalide is an octapeptide fragment of cholestocystokinin (CCK) that activates the CCK receptor on immune cell surfaces. Sincalide is more potent when sulfated. Sincalide exhibits neuroprotective, immunosuppressive, and anorexigenic activities.
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| CAT# | R1676 |
| Chemical Structure |  |
| CAS | 25126-32-3 |
| Synonyms/Alias | Cholecystokinin (26-33), CCK Octapeptide, sulfated;D-Y(SO3H)-MGWMDF-NH2; 3-amino-4-[[1-[[1-[[2-[[1-[[1-[[1-[(1-amino-1-oxo-3-phenylpropan-2-yl)amino]-3-carboxy-1-oxopropan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-1-ox |
| M.F/Formula | C49H62N10O16S3 |
| M.W/Mr. | 1143.27 |
| Sequence | One Letter Code: D-SO3H-Tyr-MGWMDF-NH2
three Letter Code: Asp-SO3H-Tyr-Met-Gly-Trp-Met-Asp-Phe-NH2 |
| Biological Activity | Sincalide (Cholecystokinin octapeptide) is a rapid-acting amino acid polypeptide hormone analogue of cholecystokinin (CCK) for intravenous use in postevacuation cholecystography. Sincalide ammonium is an agent that promotes gallbladder contraction by injection and helps diagnose gallbladder and pancreas disorders. The hepatobiliary physiologic effect of Sincalide ammonium is to increase bile secretion, cause the gallbladder to contract and relax the sphincter of Oddi, resulting in bile drainage into the duodenum. |
| Storage | Desiccate at -20°C |
Shipping Condition | Room temperature in continental US; may vary elsewhere. |
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