We use cookies to understand how you use our site and to improve the overall user experience. This includes personalizing content and advertising. Read our Privacy Policy
CAT# | Product Name | M.W | Molecular Formula | Inquiry |
---|---|---|---|---|
O02001 | Orexin A, bovine, human, mouse, rat | 3561.2 | C152H243N47O44S4 | Inquiry |
O02003 | Orexin B, canine | 2909.4 | C125H214N44O34S1 | Inquiry |
O02005 | (Ala11,D-Leu15)-Orexin B (human) | 2857.3 | Inquiry | |
O02006 | Hypocretin (70-98) (human) | 2957.41 | Inquiry |
In 1998, the endogenous ligand of orexin (also known as hypocretin) as two orphan G protein-coupled receptors were discovered through reverse pharmacology. Orexin-A and orexin-B are two molecular forms of orexin, which derive from the same 130-aa residue precursor (proorexin-orexin). Orexin-A is a 33-aa residue peptide with two intrachain disulfide bonds, which is completely conserved in quadruped animals, Orexin-B is a linear 28-aa residue peptide. Orexin can particularly bind to orexin receptors OX1R and OX2R. OX1R and OX2R have high appetency for orexin-A, while OX2R is alternative combines by orexin-B with alike high appetency. The orexin system plays an important role in metabolism, drinking behavior, endocrine system, regulation of eating and sleep-wake cycle.
Orexin-1 receptor and orexin-2 receptor are two G protein-coupled receptors. Only when orexin binds to these two receptors can its physiological function be reflected. By deleting the proorexin-orexin or orexin-2 receptor genes or by eliminating orexin neurons, the orexin signal is damaged, leading to sleep disorders similar to narcolepsy, suggesting that the orexin system plays an important role in sleep/wakefulness accommodation. Besides, orexins are related to emotional accommodate, encouragement and pressure answer, liquid and energy stabilization. There is increasing proof show that orexin impacts the function of peripheral tissues by directly activating autonomic nervous system or by activating orexin receptor or endocrine system.
Orexins have various roles and influence many functions including autonomic regulation, endocrine function, food intake, appetite, wakefulness, and sleep. Orexins and their receptors are present in a wide range of organs outside the CNS. These molecules are involved in various physiological mechanisms. Based on the current findings, there is strong evidence supporting their functional roles in the periphery. Moreover, many studies have shown that disturbances in the expression or the levels of orexin peptides can result in pathological disorders such as late-onset obesity, impaired insulin sensitivity, hyperinsulinemia, and disturbances in gut function.
References
USA
Address: SUITE 115, 17 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-624-4882
Fax: 1-631-614-7828
Email: info@creative-peptides.com
Germany
Address: Industriepark Höchst, Gebäude G830
65929 Frankfurt am Main
Email: info@creative-peptides.com