Novexatin (NP213)

Novexatin (NP213) is a rapidly acting, novel, first-in-class synthetic antimicrobial peptide (AMP), has anti-fungal activities. NP213 targets the fungal cytoplasmic membrane and plays its role via membrane perturbation and disruption. NP213 is effective and well-tolerated in resolving nail fungal infections.

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CAT#	R1890
CAS	942577-31-3
Synonyms/Alias	NP-213; NP213; NP 213; Novexatin
Chemical Name	2-[3-[(2S,5S,8S,11S,14S,17S,20S)-5,8,11,14,17,20-hexakis[3-(diaminomethylideneamino)propyl]-3,6,9,12,15,18,21-heptaoxo-1,4,7,10,13,16,19-heptazacyclohenicos-2-yl]propyl]guanidine
M.F/Formula	C42H84N28O7
M.W/Mr.	1093.32
Sequence	One Letter Code: Cyclo-RRRRRRR Three Letter Code: Cyclo-{Arg}{Arg}{Arg}{Arg}{Arg}{Arg}{Arg}
Appearance	Solid powder
Purity	>98%

CAT#	Product Name	Inquiry
R1988	Emfilermin	Inquiry
R1654	ReACp53	Inquiry
PI-002	Angiopep-2	Inquiry
R1567	NT 13	Inquiry
R1136	123C4	Inquiry

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Storage	-20 °C or below
Solubility	10 mM in DMSO
Shipping Condition	RT, or blue ice upon request.
InChI	InChI=1S/C42H84N28O7/c43-36(44)57-15-1-8-22-29(71)65-24(10-3-17-59-38(47)48)31(73)67-26(12-5-19-61-40(51)52)33(75)69-28(14-7-21-63-42(55)56)35(77)70-27(13-6-20-62-41(53)54)34(76)68-25(11-4-18-60-39(49)50)32(74)66-23(30(72)64-22)9-2-16-58-37(45)46/h22-28H,1-21H2,(H,64,72)(H,65,71)(H,66,74)(H,67,73)(H,68,76)(H,69,75)(H,70,77)(H4,43,44,57)(H4,45,46,58)(H4,47,48,59)(H4,49,50,60)(H4,51,52,61)(H4,53,54,62)(H4,55,56,63)/t22-,23-,24-,25-,26-,27-,28-/m0/s1
InChI Key	NVZLKNHDHPPJHL-RMIXPHLWSA-N
Canonical SMILES	N/C(N)=N\CCC[C@@H](C(N[C@@H](CCC/N=C(N)\N)C(N[C@@H](CCC/N=C(N)\N)C(N[C@@H](CCC/N=C(N)\N)C(N[C@@H](CCC/N=C(N)\N)C(N[C@@H](CCC/N=C(N)\N)C(N[C@H]1CCC/N=C(N)\N)=O)=O)=O)=O)=O)=O)NC1=O