Fostamatinib
Fostamatinib works by inhibiting spleen tyrosine kinase (SYK), which plays a role in the immune response. By blocking this enzyme, fostamatinib helps to reduce the destruction of platelets by the immune system, thereby increasing platelet counts in patients with ITP.
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| CAT# | R2245 |
| CAS | 901119-35-5 |
| Chemical Name | [6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)pyrimidin-4-yl]amino]-2,2-dimethyl-3-oxopyrido[3,2-b][1,4]oxazin-4-yl]methyl dihydrogen phosphate |
| M.F/Formula | C23H26FN6O9P |
| M.W/Mr. | 580.46 |
| Appearance | White to off-white Solid |
| Target | Syk, FLT3 |
| InChI | InChI=1S/C23H26FN6O9P/c1-23(2)21(31)30(11-38-40(32,33)34)20-14(39-23)6-7-17(28-20)27-19-13(24)10-25-22(29-19)26-12-8-15(35-3)18(37-5)16(9-12)36-4/h6-10H,11H2,1-5H3,(H2,32,33,34)(H2,25,26,27,28,29) |
InChI Key | GKDRMWXFWHEQQT-UHFFFAOYSA-N |
Canonical SMILES | CC1(C(=O)N(C2=C(O1)C=CC(=N2)NC3=NC(=NC=C3F)NC4=CC(=C(C(=C4)OC)OC)OC)COP(=O)(O)O)C |
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