Fibrinopeptides
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Fibrinopeptides A and B (FPA and FPB) are short amino acid sequences located at the amino ends of soluble fibrin α chain and β chain. Fibrinopepide-A (FPA) is a kind of fibrin peptide A, which is composed of 1 to 16 amino acids by the cleavage of the peptide chain between sperm-16 and Gan-17 of the α-(A) chain of fibrin under the action of thrombin. The fibrinopeptide A is a kind of fibrin peptide A, which is composed of 1 to 16 amino acids. It is a reliable index to reflect the coagulation activity in vivo and the final formation of thrombus by fibrin.
Mode of Action
Fibrinogen (Fbg) is one of the most abundant proteins in blood, which plays a key role in hemostasis, inflammation, wound healing and other physiological and pathological processes. When the blood comes into contact with the artificial material or the injured blood vessel wall, the fibrinogen is quickly adsorbed on the surface and interacts with the adherent activated platelets and subendothelial proteins. A large number of studies have shown that the Fibrinogen in the solution and the Fibrinogen adsorbed on different surfaces show different properties. For example, the fibrin adsorbed on the surface changes its conformation, thus revealing multiple binding sites that interact with receptors on platelets and leukocytes. These interactions are involved in the formation of blood clots and inflammation. The effect of fibrin deposition on platelet adhesion may be related to the occurrence of inflammatory reaction during ischemia-reperfusion. The structural properties of fibrinogen play a key role in its interaction with various biomolecules and cell types.
Application of Fibrinopeptides
The increase of plasma fibrinopeptide A level is related to disseminate intravascular coagulation, deep venous thrombosis, arterial thrombosis and malignant tumor. Because the half-life of FPA in plasma is very short (3-5 minutes), and the conversion of fibrinogen to fibrin is particularly rapid and early in the process of thrombosis. Therefore, the determination of the increase of FPA levels in samples obtained very early after the onset of transmural infarction symptoms will be helpful to evaluate the relationship between acute coronary artery thrombosis and acute coronary artery thrombosis. Elevated FPA level may be a sign of coronary artery thrombosis.
References
- Commodore, J. J., & Cassady, C. J. (2016). The effects of trivalent lanthanide cationization on the electron transfer dissociation of acidic fibrinopeptide B and its analogs. Journal of The American Society for Mass Spectrometry, 27(9), 1499-1509.
- Zhao, J., Xu, S. Z., & Liu, J. (2019). Fibrinopeptide A induces C‐reactive protein expression through the ROS‐ERK1/2/p38‐NF‐κB signal pathway in the human umbilical vascular endothelial cells. Journal of cellular physiology.
