Etelcalcetide
Etelcalcetide is used for the treatment of secondary hyperparathyroidism in patients with chronic kidney disease (CKD) on hemodialysis. Etelcalcetide is a calcimimetic agent that allosterically modulates the calcium-sensing receptor (CaSR). Etelcalcetide binds to the CaSR and enhances activation of the receptor by extracellular calcium. Activation of the CaSR on parathyroid chief cells decreases PTH secretion.
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| CAT# | 10-101-140 |
| Chemical Structure |  |
| CAS | 1262780-97-1 |
| Synonyms/Alias | Velcalcetide; telcalcetide; AMG-416; KAI-4169; ONO-5163 |
| M.F/Formula | C38H73N21O10S2 |
| M.W/Mr. | 1048.26 |
| Sequence | Three Letter Code: H-Cys(1)-OH . Ac-D-Cys(1)-D-Ala-D-Arg-D-Arg-D-Arg-D-Ala-D-Arg-NH2 |
| Application | Etelcalcetide is a calcium-sensing receptor agonist that indicated for Secondary hyperparathyroidism (HPT) in adult patients with chronic kidney disease (CKD) on hemodialysis. |
| Appearance | Solid powder |
| Activity | Activator |
| Biological Activity | Etelcalcetide is a calcium-sensing receptor agonist for the treatment of secondary hyperparathyroidism for patients with chronic kidney disease (CKD) on hemodialysis. Etelcalcetide is a synthetic octapeptide composed of a linear chain of seven d-amino acids with the N-terminal d-cysteine linked to an l-cysteine via a covalent disulfide bond. |
| Target | CaSR |
| Storage | Desiccate at -20°C |
Shipping Condition | Room temperature in continental US; may vary elsewhere. |
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