Astressin 2B

Selective and potent antagonist of corticotropin-releasing factor receptor 2 (CRF2) (IC50 values are 1.3 and > 500 nM for CRF2 and CRF1 respectively) that antagonizes CRF2-mediated inhibition of gastric emptying.

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CAT#R1100
CAS681260-70-8
M.F/FormulaC183H307N49O53
M.W/Mr.4041.69
SequenceDLSFHLLRKXIEIEKQEKEKQQAENNKLLLDLI(Modifications: Asp-1 = N-terminal Ac, Phe-4 = D-Phe, Leu-6 = α-methyl-Leu, X = Nle, Glu-24 = γ-Glu, Lys-27 = ε-Lys, Leu-32 = α-methyl-Leu, Lactam Bridge = Glu-24 - Lys-27)
Labeling TargetCorticotropin-releasing factor receptor 2 (CRF2)
AppearanceWhite lyophilised solid
Purity>98%
ActivityAntagonist
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