Taltirelin is a thyrotropin-releasing hormone (TRH) analog, which mimics the physiological actions of TRH, but with a much longer half-life and duration of effects.
CAT# | 10-101-63 |
CAS | 103300-74-9 |
Background | Taltirelin is a synthetic thyrotropin-releasing hormone (TRH) analog. Displays ~ 30-100-fold more potent CNS activity and ~ 50-fold weaker endocrine activity than TRH. Both antinociceptive and neuroprotective. >> Read More |
Synonyms/Alias | taltirelin hydrate; (1-methyl-4,5-dihydroorotyl)-histidyl-prolinamide; TA-0910; TA 0910; LS-118853 |
M.F/Formula | C17H23N7O5 |
M.W/Mr. | 477.46 |
Sequence | (1-methyl-4,5-dihydroorotyl)- His-Pro-NH2 |
Labeling Target | Thyrotropin-releasing hormone (TRH) receptors |
Application | Taltirelin (marketed under the tradename Ceredist) has nootropic, neuroprotective and analgesic effects. |
Activity | Agonist |
Biological Activity | Taltirelin (TA0910) is a superagonist at thyrotropin-releasing hormone receptor (TRH-R) with an IC50 of 910 nM and EC50 of 36 nM for stimulating an increase in cytosolic Ca2+ concentration (Ca2+ release). |
Areas of Interest | Neurological Disease |
Target | Thyroid Hormone Receptor |
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