NNMTi
NNMTi is a nicotinamide N-methyltransferase (NNMT) inhibitor that promotes myoblast differentiation.
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| CAT# | R1939 |
| Chemical Structure |  |
| CAS | 42464-96-0 |
| Synonyms/Alias | 5-Amino-1-methylquinolinium iodide |
| Chemical Name | 1-methylquinolin-1-ium-5-amine;iodide |
| M.F/Formula | C10H11IN2 |
| M.W/Mr. | 286.11 |
| Appearance | Solid powder |
| Biological Activity | Nicotinamide N-methyltransferase (NNMT) inhibitor (IC50 = 1.2 μM). Promotes myoblast differentiation in C2C12 cells. Activates senescent muscle stem cells (muSCs) and improves regenerative capacity of aged skeletal muscle. Enhances proliferation, fusion and regenerative capacity of muSCs in aged mice. |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
Solubility | Soluble in DMSO |
Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
InChI | InChI=1S/C10H10N2.HI/c1-12-7-3-4-8-9(11)5-2-6-10(8)12;/h2-7,11H,1H3;1H |
InChI Key | JPEZFBFIRRAFNR-UHFFFAOYSA-N |
Canonical SMILES | C[N+]1=CC=CC2=C(C=CC=C21)N.[I-] |
References | 1. Neelakantan et al (2019) Small molecule nicotinamide N-methyltransferase inhibitor activates senescent muscle stem cells and improves regenerative capacity of aged skeletal muscle. Biochem. Pharmacol. 163 481 PMID: 30753815
2.Neelakantan et al (2017) Structure-activity relationship for small molecule inhibitors of nicotinamide N-methyltransferase. J.Med.Chem. 60 5015 PMID: 28548833 |
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