AF 12198 is a peptide that selectively binds Interleukin-1 (IL-1) receptor and blocks in vivo responses to IL-1. The interleukin-1 receptor can activate the innate immune response by binding to cytokines. Dysregulation of cytokine production can lead to aberrant immune cells activation that could result in auto-inflammatory disorders. AF 12198 shows anti-inflammatory activity in vivo.
CAT# | R0918 |
CAS | 185413-30-3 |
Synonyms/Alias | N-Acetyl-L-phenylalanyl-L-α-glutamyl-L-tryptophyl-L-threonyl-L-prolylglycyl-L-tryptophyl-L-tyrosyl-L-glutaminyl-(2S)-2-azetidinecarbonyl-L-tyrosyl-L-alanyl-L-leucyl-L-prolyl-L-Leucinamide |
M.F/Formula | C96H123N19O22 |
M.W/Mr. | 1895.14 |
Sequence | FEWTPGWYQXYALPL(Modifications: Phe-1 = N-terminal Ac, X - Aze, Leu-15 = C-terminal amide) |
Labeling Target | Interleukin-1 (IL-1) receptor |
Appearance | White to Off-White Solid |
Purity | >98% |
Activity | Antagonist |
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