AF 12198

AF 12198 is a peptide that selectively binds Interleukin-1 (IL-1) receptor and blocks in vivo responses to IL-1. The interleukin-1 receptor can activate the innate immune response by binding to cytokines. Dysregulation of cytokine production can lead to aberrant immune cells activation that could result in auto-inflammatory disorders. AF 12198 shows anti-inflammatory activity in vivo.

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CAT#R0918
CAS185413-30-3
Synonyms/AliasN-​Acetyl-​L-​phenylalanyl-​L-​α-​glutamyl-​L-​tryptophyl-​L-​threonyl-​L-​prolylglycyl-​L-​tryptophyl-​L-​tyrosyl-​L-​glutaminyl-​(2S)​-​2-​azetidinecarbonyl-​L-​tyrosyl-​L-​alanyl-​L-​leucyl-​L-​prolyl-L-​Leucinamide
M.F/FormulaC96H123N19O22
M.W/Mr.1895.14
SequenceFEWTPGWYQXYALPL(Modifications: Phe-1 = N-terminal Ac, X - Aze, Leu-15 = C-terminal amide)
Labeling TargetInterleukin-1 (IL-1) receptor
AppearanceWhite to Off-White Solid
Purity>98%
ActivityAntagonist
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