Teriparatide Acetate is a bone-forming peptide supporting osteoporosis research. Buy Teriparatide peptide online to study bone growth and calcium metabolism.
CAT No: 10-101-54
CAS No:52232-67-4 (net), 99294-94-7 (hydrate)
Synonyms/Alias:PTH (1-34) (human),Human parathormone(1-34),Human PTH(1-34),HPTH-(1-34)
Teriparatide Acetate is a synthetic peptide analog of the biologically active fragment of human parathyroid hormone (PTH 1-34), renowned for its potent regulatory effects on calcium and phosphate metabolism. As a member of the peptide compound category, it closely mimics the endogenous hormone's structure and function, making it a valuable tool in various biochemical and physiological research contexts. Its ability to activate the parathyroid hormone 1 receptor (PTH1R) has positioned it as a fundamental reagent for exploring bone remodeling, mineral homeostasis, and signal transduction pathways associated with PTH activity. Due to its well-characterized sequence and receptor specificity, Teriparatide Acetate supports a wide range of scientific investigations into peptide-receptor interactions and downstream cellular responses.
Bone Metabolism Research: Teriparatide Acetate is extensively utilized in studies focused on bone biology, particularly those examining the molecular mechanisms governing bone formation and resorption. By engaging PTH1R on osteoblasts and osteocytes, it enables researchers to dissect the signaling cascades that regulate osteogenic differentiation, matrix mineralization, and the balance between bone anabolism and catabolism. Its application facilitates detailed analysis of how intermittent versus continuous peptide exposure differentially modulates skeletal tissue dynamics, providing insight into the physiological regulation of bone mass and architecture.
Signal Transduction Studies: The peptide's well-defined interaction with the PTH1R makes it an ideal probe for elucidating G protein-coupled receptor (GPCR) signaling pathways. Researchers employ Teriparatide Acetate to investigate downstream effectors such as cyclic AMP (cAMP) production, protein kinase A activation, and gene expression changes in target cells. These studies contribute to a deeper understanding of receptor pharmacology, ligand-receptor specificity, and the broader implications of PTH signaling in diverse tissues beyond bone, including kidney and cardiovascular systems.
Peptide Receptor Binding Assays: Due to its high receptor affinity and selectivity, Teriparatide Acetate serves as a reference ligand in competitive binding assays and receptor occupancy studies. Utilizing radiolabeled or fluorescently tagged analogs, scientists can quantitatively assess PTH1R density, distribution, and ligand-binding kinetics in various cell types or tissue preparations. Such assays are pivotal for characterizing novel PTH analogs, mapping receptor expression patterns, and validating assay platforms for high-throughput screening.
Peptide Synthesis and Analytical Method Development: In peptide chemistry research, Teriparatide Acetate is employed as a model peptide for optimizing solid-phase peptide synthesis (SPPS) protocols and purification strategies. Its defined sequence and biological activity make it suitable for validating chromatographic methods, mass spectrometric analyses, and peptide quantification techniques. Analytical laboratories benefit from its use as a positive control or standard in method development, ensuring the reliability and reproducibility of peptide-based assays.
Pharmacological Screening and Structure-Activity Relationship (SAR) Studies: The compound is frequently incorporated into in vitro and ex vivo experimental systems to evaluate the pharmacological profiles of new PTH analogs or peptide mimetics. By comparing the activity of Teriparatide Acetate with structurally modified derivatives, researchers gain valuable insights into the structure-activity relationships that dictate receptor binding, signal transduction efficacy, and selectivity. These investigations support the rational design of novel peptides with tailored biological properties for research applications in endocrinology, bone physiology, and peptide therapeutics development.
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