Elcatonin Acetate is a calcitonin analog supporting bone metabolism research. Buy Elcatonin peptide online to study calcium regulation and osteoporosis.
CAT No: 10-101-13
CAS No:60731-46-6 (net)
Synonyms/Alias:Carbocalcitonin; Elcatonine; Elcatoninum; Elcatonina; HC-58; HC58; HC 58; LS-61711; LS61711; LS 61711;DL-cysteinyl-DL-seryl-DL-asparagyl-DL-leucyl-DL-seryl-DL-threonyl-DL-cysteinyl-DL-valyl-DL-leucyl-glycyl-DL-lysyl-DL-leucyl-DL-seryl-DL-glutaminyl-DL-alpha-glutamyl-DL-leucyl-DL-histidyl-DL-lysyl-DL-leucyl-DL-glutaminyl-DL-threonyl-DL-tyrosyl-DL-prolyl-DL-arginyl-DL-threonyl-DL-alpha-aspartyl-DL-valyl-glycyl-DL-alanyl-glycyl-DL-threonyl-DL-prolinamide (1->7)-disulfide
Chemical Name:4-[[5-amino-2-[[2-[[2-[[6-amino-2-[[2-[[2-[[2-[[22-amino-16-(2-amino-2-oxoethyl)-7-(1-hydroxyethyl)-10,19-bis(hydroxymethyl)-13-(2-methylpropyl)-6,9,12,15,18,21-hexaoxo-1,2-dithia-5,8,11,14,17,20-hexazacyclotricosane-4-carbonyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]acetyl]amino]hexanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxypropanoyl]amino]-5-oxopentanoyl]amino]-5-[[1-[[1-[[6-amino-1-[[1-[[5-amino-1-[[1-[[1-[2-[[5-carbamimidamido-1-[[1-[[1-[[1-[[2-[[1-[[2-[[1-(2-carbamoylpyrrolidin-1-yl)-3-hydroxy-1-oxobutan-2-yl]amino]-2-oxoethyl]amino]-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-3-methyl-1-oxobutan-2-yl]amino]-3-carboxy-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxopentan-2-yl]carbamoyl]pyrrolidin-1-yl]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxohexan-2-yl]amino]-3-(1H-imidazol-4-yl)-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-oxopentanoic acid
Elcatonin Acetate is a synthetic peptide derivative structurally related to eel calcitonin, distinguished by its potent activity in modulating calcium and bone metabolism. As a member of the calcitonin peptide family, it exhibits enhanced stability and biological activity compared to native mammalian calcitonins, making it a valuable tool in biochemical and physiological research. Its unique amino acid sequence and acetylated form confer distinct pharmacodynamic properties, supporting its widespread adoption in studies investigating peptide hormone signaling, receptor interactions, and calcium regulatory pathways. The compound is widely utilized in academic, pharmaceutical, and industrial research settings to elucidate the mechanisms underlying bone remodeling, mineral homeostasis, and peptide-receptor pharmacology.
Peptide hormone research: Elcatonin Acetate is extensively applied in the study of peptide hormone activity, particularly regarding its interaction with calcitonin receptors on osteoclasts and renal cells. Researchers employ this peptide to dissect the molecular mechanisms by which calcitonin analogs modulate cellular signaling cascades, such as the inhibition of osteoclastic bone resorption or the regulation of renal calcium excretion. Its high affinity and specificity for calcitonin receptors enable detailed investigation into receptor-ligand dynamics, downstream effector pathways, and the structural basis for agonist selectivity within the calcitonin family.
Bone metabolism studies: The compound serves as a critical tool in exploring the regulation of bone turnover and mineralization. By acting as a potent inhibitor of osteoclastic activity, Elcatonin Acetate facilitates experimental modeling of bone resorption processes in vitro and in animal models. Researchers leverage its robust anti-resorptive effects to examine the cellular and molecular determinants of bone density, the interplay between osteoblasts and osteoclasts, and the impact of exogenous peptides on skeletal homeostasis. Such studies are instrumental in advancing the understanding of bone physiology and the development of novel biomaterials or bone-targeting agents.
Receptor binding assays: Elcatonin Acetate is frequently utilized in receptor binding and competition assays to characterize the affinity, specificity, and kinetics of calcitonin receptor-ligand interactions. Its stable peptide structure and well-defined activity profile make it an ideal reference compound for validating assay systems, benchmarking new calcitonin analogs, or quantifying receptor expression in various cell types. These applications are valuable in high-throughput screening platforms, structure-activity relationship analyses, and the optimization of peptide-based ligands for research or development purposes.
Peptide stability and formulation research: The acetylated form of Elcatonin provides enhanced resistance to proteolytic degradation, making it a model compound for investigating peptide stability, formulation strategies, and delivery systems. Researchers utilize it to assess the impact of chemical modifications on peptide half-life, solubility, and bioactivity under different storage or experimental conditions. This knowledge is critical for the rational design of peptide therapeutics, improved drug delivery vehicles, and the development of novel excipients or stabilizing agents for peptide drugs.
Analytical method development: The compound is also incorporated into analytical method validation for peptide quantification and characterization. Laboratories employ Elcatonin Acetate as a standard or control in chromatographic, spectrometric, or immunological assays designed to detect and quantify peptide hormones in complex biological samples. Its defined sequence and stability facilitate the calibration of analytical instruments, assessment of assay sensitivity, and benchmarking of new analytical technologies targeting peptide biomolecules. Such applications support rigorous quality control and reproducibility in peptide research workflows.
The polypeptide hormone calcitonin is clinically well known for its ability to relieve neuropathic pain such as spinal canal stenosis, diabetic neuropathy and complex regional pain syndrome. Mechanisms for its analgesic effect, however, remain unclear. Here we investigated the mechanism of anti-hyperalgesic action of calcitonin in a neuropathic pain model in rats.
Ito, A., Takeda, M., Yoshimura, T., Komatsu, T., Ohno, T., Kuriyama, H., ... & Yoshimura, M. (2012). Anti-hyperalgesic effects of calcitonin on neuropathic pain interacting with its peripheral receptors. Molecular pain, 8(1), 42.
The study was carried out to determine the effect of a combination regimen of a small dose of calcitonin added to conjugated estrogens with medroxyprogesterone acetate on vertebral bone mass in early postmenopausal women. Comparisons were made with groups of women on calcitonin alone, on conjugated estrogens with medroxyprogesterone acetate alone, or on no treatment. The study was carried out over a 2-year period. The results of the study suggest that the combined regimen of calcitonin and estrogens increased vertebral bone mass in early postmenopausal women to a greater extent than calcitonin alone or estrogen alone. Increases in vertebral bone mass of 11.2% after 1 year and 9.2% after 2 years were demonstrated using the combined regimen. Both estrogens alone and calcitonin alone were, however, very effective in preventing rapid bone loss in the postmenopausal women studied.
Meschia, M., Brincat, M., Barbacini, P., Crossignani, P. G., & Albisetti, W. (1993). A clinical trial on the effects of a combination of elcatonin (carbocalcitonin) and conjugated estrogens on vertebral bone mass in early postmenopausal women. Calcified tissue international, 53(1), 17-20.
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