Buserelin Acetate is a GnRH agonist peptide regulating reproductive hormones. Buy Buserelin peptide powder online to explore fertility and hormone-dependent tumor research.
CAT No: 10-101-07
CAS No:57982-77-1 (net), 68630-75-1 (acetate)
Synonyms/Alias:Buserelin acetate;68630-75-1;Suprecur;Suprefact;Buserelin monoacetate;Buserelin (Acetate);Conceptal;Profact;HOE 766MP;HOE 766 MP;UNII-13U86G7YSP;NSC-725176;13U86G7YSP;HOE 766;HOE-766;Receptal;CHEBI:31324;DTXSID30218712;NSC 725176;BUSERELIN ACETATE (MART.);BUSERELIN ACETATE [MART.];Estomal;Acetate, Buserelin;Buserelin acetate [USAN:JAN];NSC725176;Suprefact Depot;Profact Depot;Suprefact Flakon;BSRL Acetate;Suprecur (TN);Hoe-766 MP;5-Oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-O-tert-butyl-D-seryl-L-leucyl-L-arginyl-N-ethyl-L-prolinamide monoacetate (salt);SCHEMBL167553;Buserelin acetate (JAN/USAN);BUSERELIN ACETATE [JAN];BUSERELIN ACETATE [USAN];CHEMBL2106198;DTXCID80141203;PYMDEDHDQYLBRT-DRIHCAFSSA-N;BUSERELIN MONOACETATE [MI];BUSERELIN ACETATE [WHO-DD];HY-13581A;MFCD01716229;AKOS032960353;AKOS040763961;AT41853;CS-5962;FP19363;DA-51475;TS-10343;NS00036669;Buserelin Acetate (57982-77-1 free base);D01831;D-Ser (Bu(t))(6) Pro(9) NEt LHRH Acetate;(Des-Gly10,D-Ser(tBu)6,Pro-NHEt9)-LHRH Acetate;Q27888490;(2S)-1-[(2S)-2-[(2S)-2-[(2R)-3-(TERT-BUTOXY)-2-[(2S)-2-[(2S)-3-HYDROXY-2-[(2S)-2-[(2S)-3-(1H-IMIDAZOL-4-YL)-2-{[(2S)-5-OXOPYRROLIDIN-2-YL]FORMAMIDO}PROPANAMIDO]-3-(1H-INDOL-3-YL)PROPANAMIDO]PROPANAMIDO]-3-(4-HYDROXYPHENYL)PROPANAMIDO]PROPANAMIDO]-4-METHYLPENTANAMIDO]-5-CARBAMIMIDAMIDOPENTANOYL]-N-ETHYLPYRROLIDINE-2-CARBOXAMIDE; ACETIC ACID;pGlu-His-Trp-Ser-Tyr-D-Ser(t-Bu)-Leu-Arg-Pro-NHEt acetate salt;Estomal;pGlu-His-Trp-Ser-Tyr-D-Ser(t-Bu)-Leu-Arg-Pro-NHEt acetate sal t;6-[O-(1,1-Dimethylethyl)-D-serine]-9-(N-ethyl-L-prolinamide)-1-9-luteinizing hormone-releasing factor monoacetate;
Chemical Name:acetic acid;(2S)-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2R)-1-[[(2S)-1-[[(2S)-5-(diaminomethylideneamino)-1-[(2S)-2-(ethylcarbamoyl)pyrrolidin-1-yl]-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-[(2-methylpropan-2-yl)oxy]-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide
Buserelin Acetate is a synthetic decapeptide analog of gonadotropin-releasing hormone (GnRH), designed to mimic the endogenous hormone's activity with enhanced stability and receptor affinity. As a potent agonist of the GnRH receptor, it exhibits a critical role in modulating the hypothalamic-pituitary-gonadal axis, making it a valuable tool in both fundamental and applied endocrine research. The compound's structural modifications confer increased resistance to enzymatic degradation, extending its half-life and functional activity in experimental systems. Its precise mechanism of action and well-characterized receptor interactions have established Buserelin Acetate as an essential reagent for dissecting neuroendocrine pathways, hormonal feedback mechanisms, and receptor pharmacology in vitro and in vivo. As such, it is widely recognized for its contribution to advancing the understanding of peptide hormone signaling and regulatory networks.
Endocrine Regulation Studies: Buserelin Acetate is extensively utilized in experimental models to investigate the regulatory dynamics of the hypothalamic-pituitary-gonadal axis. By serving as a selective GnRH receptor agonist, it enables researchers to manipulate gonadotropin secretion, facilitating the study of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) release patterns. Its application in these systems provides critical insights into feedback loops, receptor desensitization, and downstream gene expression changes associated with hormonal control, supporting research into reproductive biology and endocrine feedback mechanisms.
Receptor Pharmacology: The compound's high affinity for GnRH receptors makes it an indispensable tool for characterizing receptor binding kinetics, signal transduction pathways, and agonist-induced receptor internalization. Buserelin Acetate's well-defined activity profile allows for detailed mapping of receptor-ligand interactions, aiding in the development of new peptide analogs and antagonists. Studies employing this analog contribute to a deeper understanding of G protein-coupled receptor (GPCR) function, ligand specificity, and receptor modulation, which are central themes in both basic science and drug discovery.
Peptide Drug Development: Buserelin Acetate serves as a reference molecule in the design and optimization of novel peptide therapeutics targeting the GnRH receptor. Its structural features and functional properties inform structure-activity relationship (SAR) studies, guiding the rational modification of peptide backbones for improved potency, selectivity, and metabolic stability. By benchmarking new analogs against Buserelin Acetate, researchers can systematically assess efficacy and receptor selectivity, accelerating the preclinical development of next-generation GnRH-targeted agents.
Cell Signaling Research: The ability of Buserelin Acetate to activate intracellular signaling cascades downstream of the GnRH receptor is leveraged in studies focused on elucidating the molecular mechanisms of hormone action. It is commonly employed to trigger defined signaling events in cultured pituitary or hypothalamic cells, enabling the analysis of second messenger systems, kinase activation, and gene regulatory networks. Such applications are vital for unraveling the complexities of neuroendocrine signal integration and the broader physiological consequences of GnRH receptor activation.
Analytical and Bioassay Standardization: Due to its stability and reproducible bioactivity, Buserelin Acetate is frequently used as a calibration standard or positive control in bioassays measuring GnRH receptor function. Its inclusion in assay protocols ensures consistency and comparability across experimental runs, supporting the validation of assay performance and the quantification of receptor-mediated responses. This application is particularly important in high-throughput screening, pharmacological profiling, and quality control settings, where reliable reference compounds are essential for robust data interpretation.
Buserelin acetate appears to cause a progressive blockade of gonadotrophin secretion when administered to female rats for four, eight or 12 days, and an important rebound effect, with accentuated estrogen release already apparent in the first estrous cycle following treatment.
Trindade C R, Camargos A F, Pereira F E L. The effect of buserelin acetate on the uterus of adult rats: morphological aspects[J]. Clin Exp Obstet Gynecol, 2008, 3: 198-201.
A comparison has been established retrospectively between clomiphene citrate-human menopausal gonadotropin (CC-hMG) and buserelin acetate-hMG treatments in in vitro fertilization trials performed over a 3-year period. The analysis of 466 CC-hMG and 319 buserelin acetate-hMG trials shows that buserelin acetate-hMG stimulation generates a greater ovarian response resulting in higher numbers of oocytes being retrieved (6.2 + 3.8 versus 9.3 + 5.2) and fertilized (2.8 + 2.7 versus 4.3 + 3.8). More embryos are thus obtained, allowing a wider choice for intrauterine replacement and cryopreservation. Mean embryonic vitality scores do not differ (4.33 + 1.51 versus 4.44 + 1.54), implying that the embryonic quality remains similar in both treatments. A premature demise of the corpus luteum occurs in a large proportion of buserelin acetate-hMG cycles. However, when suppletive progesterone treatment is given, there is a trend toward a better implantation rate per embryo, and a significantly higher ongoing pregnancy rate is observed in relation to buserelin acetate-hMG treatment (20%) as compared with CC-hMG cycles (14%).
Lejeune B, Barlow P, Puissant F, et al. Use of buserelin acetate in an in vitro fertilization program: a comparison with classical clomiphene citrate-human menopausal gonadotropin treatment[J]. Fertility and sterility, 1990, 54(3): 475-481.
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