Carperitide is a human atrial natriuretic peptide analog for heart and kidney research. Buy Carperitide peptide online to study diuretic and cardiovascular effects.
CAT No: HB00119
CAS No:89213-87-6
Synonyms/Alias:Carperitide;89213-87-6;Cardionatrin;Atriopeptin;alpha-Atriopeptin;Atrial Natriuretic Peptide;Atriopeptins;Auriculin (peptide);Atrial natriuretic peptide A;SUN-4936;Atrial natriuretic peptides;Natriuretic peptides, atrial;Atrial natriuretic factor (99-126);Atrial natriuretic peptide-28 (human reduced);ATRIAL NATRIURETIC FACTOR;85637-73-6;SUN 4936;alpha-Human atriopeptin;Atriopeptin-28 (human);alpha-Atriopeptin (human);Human atriopeptin(1-28);Human atriopeptin(99-126);CCRIS 4930;Atrial Natriuretic Peptide human;Triopeptin (human alpha-component);Carperitide [USAN:INN];UNII-GZ8FA500J0;Cardionatrine;Carperitida;NPPA protein, human;Anp 1-28,human;Atrial natruiretic factor;Natriuretic Peptide, Atrial;Peptides, Atrial Natriuretic;SCHEMBL218549;beta-Atrial Natriuretic Peptide;GZ8FA500J0;alpha-Atrial Natriuretic Peptide;Atrial Natriuretic Factor (1-28) (human) acetate salt;atrial natriuretic factor (ANF);CHEMBL2104386;gamma-Atrial Natriuretic Peptide;CHEBI:135914;NSQLIUXCMFBZME-MPVJKSABSA-N;DTXSID201346607;DTXSID801026506;Atrial Natriuretic Factor Precursors;BDBM50230986;Atrial natriuretic peptide carperitide;AKOS024456845;AT42445;ATRIAL NATRIURETIC PEPTIDE [MI];Atriopeptin-33(rat), 1-de-L-leucine-2-de-L-alanine-3-deglycine-4-de-L-proline-5-de-L-arginine-17-L-methionine-;DA-50791;FA108602;FA110232;L-Seryl-L-leucyl-L-arginyl-L-arginyl-L-seryl-L-seryl-L-cysteinyl-L-phenylalanylglycylglycyl-L-arginyl-L-methionyl-L-aspartyl-L-arginyl-L-isoleucylglycyl-L-alanyl-L-glutaminyl-L-serylglycyl-L-leucylglycyl-L-cysteinyl-L-asparaginyl-L-seryl-L-phenylalanyl-L-arginyl-L-tyrosine cyclic(7->23)-disulfide;L-Seryl-L-leucyl-L-arginyl-L-arginyl-L-seryl-L-seryl-L-cysteinyl-L-phenylalanylglycylglycyl-L-arginyl-L-methionyl-L-aspartyl-L-arginyl-L-isoleucylglycyl-L-alanyl-L-glutaminyl-L-serylglycyl-L-leucylglycyl-L-cysteinyl-L-asparaginyl-L-seryl-L-phenylalanyl-L-arginyl-L-tyrosine cyclic(7-23)-disulfide;ATRIAL NATRIURETIC PEPTIDE [WHO-DD];NS00123867;1366000-58-9;Atrial natriuretic factor (1-28) (human) acetate;Atrial natriuretic factor (1-28) trifluoroacetate;1621001-83-9;Carperitide trifluoroacetate;H-Ser-Leu-Arg-Arg-Ser-Ser-Cys-Phe-Gly-Gly-Arg-Met-Asp-Arg-Ile-Gly-Ala- Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser- Phe-Arg-Tyr-OH trifluoroacetate (Disulfide bond);H-Ser-Leu-Arg-Arg-Ser-Ser-Cys-Phe-Gly-Gly-Arg-Met-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg-Tyr-OH acetate;
Carperitide is a synthetic peptide corresponding to human atrial natriuretic peptide (ANP), a biologically active hormone involved in the regulation of blood volume and vascular tone. As a member of the natriuretic peptide family, it plays a pivotal role in cardiovascular homeostasis by promoting natriuresis, diuresis, and vasodilation through interaction with specific natriuretic peptide receptors. Its well-characterized structure and defined biological activity make it a valuable research tool for investigating peptide signaling, receptor pharmacology, and mechanisms underlying cardiovascular and renal physiology. Carperitide's functional mimicry of endogenous ANP enables precise experimental modulation of natriuretic peptide pathways, supporting a range of biochemical and physiological research applications.
Peptide signaling studies: As a potent agonist of natriuretic peptide receptors, carperitide is widely utilized in studies aimed at elucidating the molecular mechanisms of peptide-mediated signal transduction. Researchers employ it to activate guanylyl cyclase-coupled receptors, leading to increased intracellular cyclic GMP levels. This enables detailed analysis of downstream signaling cascades, protein phosphorylation events, and gene expression changes associated with natriuretic peptide activity, facilitating a deeper understanding of cardiovascular and renal regulatory networks.
Receptor pharmacology and binding assays: Carperitide serves as a reliable ligand in receptor binding studies, allowing for the characterization of natriuretic peptide receptor subtypes, affinities, and functional responses. Its defined sequence and receptor selectivity make it suitable for competitive binding assays, receptor activation profiling, and structure-activity relationship investigations. Such applications are essential for advancing drug discovery efforts targeting natriuretic peptide pathways and for validating novel small-molecule or peptide-based receptor modulators.
Cardiovascular physiology research: The peptide is frequently used in experimental models to probe the physiological effects of natriuretic peptides on cardiac function, vascular tone, and fluid-electrolyte balance. By administering carperitide in vitro or in vivo, investigators can simulate endogenous ANP activity, enabling controlled studies of its impact on hemodynamics, endothelial function, and renal excretory mechanisms. These applications are especially relevant for dissecting the roles of natriuretic peptides in hypertension, heart failure, and related pathophysiological states.
Peptide synthesis and analytical validation: Synthetic carperitide is employed as a reference standard in peptide synthesis workflows and analytical method development. Its use ensures accurate calibration of chromatographic and mass spectrometric assays, supports quality control processes, and facilitates the validation of peptide purification protocols. Researchers and manufacturers benefit from its well-defined properties when developing or benchmarking peptide production techniques.
Cellular and molecular biology applications: In cell-based assays, carperitide is used to investigate the influence of natriuretic peptides on cellular proliferation, apoptosis, and differentiation, particularly in cardiovascular and renal cell types. Its ability to modulate intracellular signaling pathways provides insights into the regulation of gene expression, cellular metabolism, and stress responses. These studies contribute to a broader understanding of peptide hormone biology and inform the development of novel experimental models for cardiovascular and renal research.
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