Alarelin Acetate is a high-purity synthetic peptide used in fertility and ovulation research. Buy Alarelin peptide online from a trusted peptide supplier for advanced hormonal studies.
CAT No: 10-101-02
CAS No:79561-22-1
Synonyms/Alias:ALARELIN ACETATE;Alarelin (Acetate);79561-22-1;79561-22-1 (acetate); 148029-26-9 (free base).;(S)-1-((3S,6S,9S,12S,15R,18S,21S)-3-((1H-imidazol-5-yl)methyl)-6-((1H-indol-3-yl)methyl)-21-(3-((diaminomethylene)amino)propyl)-12-(4-hydroxybenzyl)-9-(hydroxymethyl)-18-isobutyl-15-methyl-1,4,7,10,13,16,19-heptaoxo-1-((S)-5-oxopyrrolidin-2-yl)-2,5,8,11,14,17,20-heptaazadocosan-22-oyl)-N-ethylpyrrolidine-2-carboxamide diacetate;Alarelin Acetate?;Alarelin (Acetate) (Standard);ALARELIN ACETATE [WHO-DD];DPWSRXJWCYEGIV-PFHUABGLSA-N;HY-17405R;Alarelin Acetate - Bio-X trade mark;AKOS030526179;CS-1172;FA64933;AS-74852;BA164142;HY-17405;
Chemical Name:acetic acid;(2S)-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2R)-1-[[(2S)-1-[[(2S)-5-(diaminomethylideneamino)-1-[(2S)-2-(ethylcarbamoyl)pyrrolidin-1-yl]-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide
Alarelin acetate is a synthetic peptide analog of gonadotropin-releasing hormone (GnRH), engineered to exhibit enhanced stability and biological activity compared to native GnRH. Structurally modified to resist rapid enzymatic degradation, this decapeptide is widely employed in biochemical and endocrinological research for its ability to modulate the hypothalamic-pituitary-gonadal (HPG) axis. Its high affinity for GnRH receptors and well-characterized mechanism of action make it a valuable tool for investigating reproductive hormone regulation, peptide-receptor interactions, and the downstream signaling pathways associated with gonadotropin release.
Reproductive endocrinology research: In laboratory settings, alarelin acetate is extensively used to stimulate or modulate the secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from pituitary cells. By mimicking endogenous GnRH, it enables precise experimental control over gonadotropin release, facilitating studies on reproductive physiology, feedback mechanisms, and the dynamics of the HPG axis in various animal models. Researchers leverage its potency and receptor selectivity to dissect the temporal patterns of hormone secretion and to model reproductive disorders in vitro and in vivo.
Peptide-receptor interaction studies: Owing to its well-defined sequence and receptor specificity, alarelin serves as an effective ligand for characterizing the binding kinetics and signal transduction properties of GnRH receptors. It is commonly used in binding assays, receptor activation studies, and structure-activity relationship (SAR) analyses to elucidate the molecular determinants of peptide-receptor affinity and efficacy. Such investigations contribute to a deeper understanding of peptide hormone pharmacology and inform the rational design of novel GnRH analogs with tailored properties.
Cell signaling pathway analysis: The compound's ability to selectively activate GnRH receptors makes it a preferred reagent for probing downstream intracellular signaling events, including the activation of G-proteins, phospholipase C, and associated second messenger cascades. By employing alarelin acetate in cellular assays, scientists can monitor specific phosphorylation events, gene expression changes, and regulatory feedback loops, thereby clarifying the mechanisms by which GnRH analogs influence cell function and endocrine regulation.
Peptide synthesis and analytical validation: Alarelin acetate is frequently used as a reference standard and positive control in peptide synthesis, purification, and analytical method development. Its defined structure and robust bioactivity provide a benchmark for validating chromatographic separation techniques, mass spectrometry protocols, and peptide quantification assays. In peptide manufacturing and quality control environments, it facilitates the calibration of instrumentation and the assessment of synthetic process efficiency, supporting the advancement of peptide-based research tools.
Comparative pharmacology and analog development: Researchers utilize alarelin acetate to benchmark the pharmacological properties of new GnRH analogs and related peptides. By comparing its receptor affinity, metabolic stability, and biological activity profiles with those of novel compounds, scientists can identify key structural features that enhance potency or selectivity. These comparative studies are essential for optimizing the next generation of peptide therapeutics and for expanding the utility of GnRH analogs in both fundamental and applied biochemical research.
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