Dihexa is a small peptide that has been developed to potently improve certain cognitive function of potential trauma-based brain disorders and neurodegenerative conditions through increased synaptogenesis.
CAT No: 10-101-343
CAS No:1401708-83-5
Synonyms/Alias:dihexa;1401708-83-5;L-Isoleucinamide, N-(1-oxohexyl)-L-tyrosyl-N-(6-amino-6-oxohexyl)-;N-hexanoic-Tyr-Ile-(6) aminohexanoic amide;9WYX65A5C2;PNB-0408;(2S,3S)-N-(6-amino-6-oxohexyl)-2-[[(2S)-2-(hexanoylamino)-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanamide;6-(2-(2-Hexanamido-3-(4-hydroxyphenyl)propanamido)-3-methylpentanamido)hexanamide;6-[(2S,3S)-2-[(2S)-2-hexanamido-3-(4-hydroxyphenyl)propanamido]-3-methylpentanamido]hexanamide;Hexanoyl-Tyr-Ile-Ahx-NH2;UNII-9WYX65A5C2;Dihexa (PNB-0408)?;DTXSID701032895;GLXC-25923;ATH-1001;AKOS040759118;CS-6864;DA-62870;HY-16969;PNB-0408; Hexanoyl-Tyr-Ile-Ahx-NH2;TS-09667;H20471;N-(1-OXOHEXYL)-L-TYROSYL-N-(6-AMINO-6-OXOHEXYL)-L-ISOLEUCINAMIDE;
Chemical Name:(2S,3S)-N-(6-amino-6-oxohexyl)-2-[[(2S)-2-(hexanoylamino)-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanamide
Dihexa is a synthetic peptide compound known for its unique structure and potent activity as a small-molecule modulator in neurobiological research. As a hexapeptide derivative, Dihexa has drawn significant attention in the scientific community due to its capacity to influence molecular pathways associated with synaptic plasticity and cognitive function. Its biochemical relevance stems from its design as an analog of angiotensin IV, enabling it to interact with specific enzymatic and receptor targets involved in memory formation and neural signaling. The compound's stability and cell permeability further enhance its utility in experimental settings, making it a valuable tool for investigating peptide-based mechanisms in the central nervous system and beyond.
Neuroscience research: Dihexa is widely utilized in studies focused on synaptic plasticity, learning, and memory. Its ability to modulate the hepatocyte growth factor (HGF)/c-Met system provides a functional platform for exploring molecular events underlying cognitive processes. Researchers employ the peptide in in vitro and ex vivo models to probe the signaling cascades that regulate dendritic spine density, synaptic connectivity, and long-term potentiation. These investigations support a deeper understanding of the biochemical substrates of cognition and facilitate the identification of novel targets for modulating neural circuit function.
Peptide mechanism elucidation: The structural features of Dihexa make it a valuable probe for dissecting peptide-receptor interactions and downstream signaling pathways. By serving as a stable, bioactive ligand, the compound enables detailed mapping of binding affinities, receptor activation profiles, and subsequent intracellular events in various cell types. Experimental use of this peptide assists in clarifying the structure-activity relationships essential for the development of next-generation neuroactive peptides, providing insights into the design of molecules with improved specificity and efficacy.
Drug discovery and screening: In pharmaceutical research environments, Dihexa is incorporated into high-throughput screening assays and lead optimization protocols. Its distinct profile as a peptide-based modulator of neurotrophic signaling allows scientists to evaluate analogs, derivatives, and combination compounds for enhanced biological activity. The compound's compatibility with both cell-based and biochemical assays makes it an effective reference standard and benchmarking tool for evaluating new chemical entities targeting related pathways.
Peptide stability and delivery studies: The physicochemical properties of Dihexa, including its resistance to enzymatic degradation and favorable membrane permeability, are of particular interest in formulation science and peptide delivery research. Scientists use it as a model compound to investigate strategies for improving the bioavailability, half-life, and tissue targeting of peptide therapeutics. These studies contribute to the broader field of peptide drug design by informing the development of delivery systems and chemical modifications that enhance peptide stability in biological environments.
Analytical method development: Due to its defined structure and robust bioactivity, Dihexa serves as a reference standard in analytical chemistry applications. Laboratories employ the peptide in the calibration and validation of chromatographic, spectrometric, and immunoassay techniques designed for the detection and quantification of peptide compounds. Its use in assay development ensures the reliability and reproducibility of experimental results, supporting a wide range of research and quality control workflows involving peptide-based analytes.
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