Animal Peptide Library
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Animal peptide library refers to a large database established by collecting and cataloguing peptide toxins produced by various toxic animals in nature. These toxins have become valuable resources in the field of drug discovery due to their high selectivity and potent activity against specific molecular targets in organisms.
As a leading biopharmaceutical company, Creative Peptides has a comprehensive library of animal peptides, covering more than 10,000 unique sequences from more than 500 different animal species, including rare and understudied organisms. We have set up a toxic animal collection, peptide active molecule discovery, peptide drug screening, peptide new drug research and development and industrialization team, in-depth exploration of animal peptides, the construction of natural active peptide molecular library, "high throughput + cloud computing" screening platform and AI artificial intelligence platform for peptide drug screening.
Characteristics of animal peptides
Venomous animals are widely distributed in nature, including snakes, spiders, scorpions, lizards, fish, and some insects, which use venom for hunting or defense. The peptide toxins in these venors have evolved over time to quickly interfere with the physiology of the prey or predator, such as causing blood clotting, pain and nerve paralysis. Animal peptides tend to have complex molecular structures, including large molecular weights (some exceeding 40 amino acids) and multiple disulfide bonds, which increase their functional diversity and present challenges for synthesis and analysis.
However, in terms of the patent drug rate, about 50,000 compounds of small molecule drugs can screen out a lead compound; However, based on natural peptides from toxic animals, it is possible to narrow down a single peptide candidate from hundreds of compounds. During the evolution of toxic animals, the peptides in the body were originally more highly active and highly selective. In addition, one reason for the low rate of small-molecule drugs is the side effect caused by off-target, but the peptides are metabolized in the body to produce amino acids, so the metabolites are not toxic.
There are currently about 60 peptide drugs on the market, with sales of $13 billion in 2010, and many more derived from animal toxins are in clinical development. These drugs provide new ways to treat conditions such as chronic pain by mimicking the mechanisms of toxin action, such as blocking pain-related ion channels.
Applications of animal peptide library
Through the high-throughput expression system, it is possible to rapidly build peptide libraries containing thousands of members, such as the more than 8,000 proteins in the conotoxin library, accelerating the process of drug discovery. The library reveals the high specificity and affinity of conotoxin to human ion channels and nervous system receptors, providing a rich library of candidate substances for drug screening, and a powerful tool and potential drug candidate for neuroscience and drug development.
By using innovative methods such as gene recombination technology and antibody fusion strategy, the limitations of traditional synthesis can be overcome to achieve efficient expression and functional optimization of specific peptide toxins. For example, using the unique structure of bovine antibody BLV1H12, which can stably insert a variety of proteins and peptides, the recombinant expression of genes such as Mexican scorpion toxin Vm24 and cobra neurotoxin cobopeptide has been successfully achieved as Kv1.3 inhibitors and long-acting analgesics, respectively.
Certain animal peptides are used in cosmetics to enhance skin health and appearance due to their specific biological activities, such as antioxidant and anti-aging effects.
The animal peptide Library is also an important resource for studying toxin mechanisms, assessing ecological risks and developing detoxification strategies to help scientists better understand the ecological role of toxic animals and how to protect humans and domestic animals from toxins.
Animal peptide library service at Creative Peptides
Design and construction of custom animal peptide library
We can custom-design and build animal peptide libraries according to the specific research needs of our customers. This includes the selection of specific amino acid sequences, lengths, modifications, etc. Through professional design and construction processes, we ensure the quality and diversity of the peptide library to meet the needs of our customers in various biomedical research.
We offer a high-throughput screening service that utilizes existing animal peptide libraries to rapidly screen target molecules (e.g., proteins, enzymes, receptors, etc.) to find peptides with specific biological activity. The high-throughput screening technology can greatly improve the screening efficiency and quickly screen candidates with potential therapeutic value from a large number of peptides.
We offer peptide synthesis services to synthesize peptides with specific sequences and modifications according to specific needs. At the same time, we also provide peptide optimization services to optimize the biological activity and stability of peptides by changing amino acid sequences, adding modifications, etc.
Study of protein-peptide interaction
Biophysical and chemical methods, such as surface plasmon resonance (SPR), isothermal titration calorimetry (ITC), circular dichroism spectroscopy (CD), were used to study the interaction between proteins and peptides, reveal the interaction mechanism and kinetic properties, and provide detailed interaction data for drug research and development and protein function research.
Immunology research service
We provide immunology-related research services, including evaluation of immune activity of peptides as antigen or vaccine candidates, analysis of peptide-induced immune responses, etc.
Why choose Creative Peptides?
- The natural animal peptide library of Creative Peptides supports the screening of highly active natural peptides with a large sample size, and continuously provides high-quality potential pharmaceutical peptides;
- Through the directional mining technology system of toxic animal traditional drugs functional components based on the biological survival strategy of Creative Peptides, highly active natural peptides can be quickly and directionally screened from the peptide library according to the actual clinical needs, mass production and transformation by chemical or biological expression, without the need to design the peptide drug sequence and conformation according to the target structure from the ground up, greatly shortening the research and development cycle.
- Delivery of most custom peptides within 2-4 weeks is promised, with expedited processing for urgent projects.
- Fluorescent labeling, phosphorylation, acetylation and other chemical modification options are available.
FAQ
1. What is an animal peptide library?
An animal peptide library is a database that contains information on peptides extracted from various animal sources. These peptides exhibit diverse biological activities and find applications in scientific research, drug development, agriculture, and the food industry, among others.
2. How are peptides collected and categorized in animal peptide libraries?
Peptides in animal peptide libraries are typically obtained through laboratory studies involving extraction from various animal tissues, cells, or fluids. They are categorized and annotated based on characteristics such as source, amino acid sequence, three-dimensional structure, and biological activity.
3. What types of information can be accessed from animal peptide libraries?
Amino acid sequences, three-dimensional structures, biological activities (e.g., antimicrobial, antiviral, anticancer), natural sources and extraction methods of peptides.
4. What are the applications of animal peptide libraries in drug development?
Peptides in animal peptide libraries possess diverse biological activities that can be utilized in drug development. For example, antimicrobial peptides can be developed into anti-infective drugs, while anticancer peptides can be explored for cancer therapy. Additionally, peptides serve as templates for drug design, providing novel therapeutic targets.
5. How do animal peptide libraries support agricultural applications?
Peptides in animal peptide libraries can be utilized in the development of biopesticides and disease-resistant crops. For instance, antimicrobial peptides can serve as natural pesticides to combat plant diseases, and specific peptides can be introduced into crops via genetic engineering to enhance disease resistance.
6. How can new peptide information be submitted to animal peptide libraries?
Most animal peptide libraries have dedicated submission systems where researchers can submit new peptide information through online forms. Submitted information typically includes peptide amino acid sequences, sources, extraction methods, biological activity data, and relevant experimental results.
7. Do animal peptide libraries provide technical support and training?
Yes, many animal peptide libraries offer technical support and training services to help users familiarize themselves with database usage and data analysis tools. These support services may include online documentation, tutorials, user forums, and customer service assistance.
