Exendin-4 (exenatide), a 39-amino acid peptide originally isolated from the salivary glands of the Gila monster (Heloderma suspectum), differs from exendin-3 only in two positions close to the N-terminus. Application of exenatide causes an increase in acinar cAMP without stimulating amylase release. As an incretin mimetic, exenatide acts as agonist of the glucagon-like peptide-1 (GLP-1) receptor. As GLP-1, though with prolonged activity, exenatide augments the postprandial production of insulin and suppresses secretion of glucagon. For this reason, exenatide has found use as a medication of diabetes II.
CAT No: 10-101-16
CAS No: 141732-76-5
Synonyms/Alias: Exenatide;141758-74-9;9P1872D4OL;141732-76-5;Exenatida;L-Serinamide, L-histidylglycyl-L-alpha-glutamylglycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-alpha-aspartyl-L-leucyl-L-seryl-L-lysyl-L-glutaminyl-L-methionyl-L-alpha-glutamyl-L-alpha-glutamyl-L-alpha-glutamyl-L-alanyl-L-valyl-L-arginyl-L-leucyl-L-phenylalanyl-L-isoleucyl-L-alpha-glutamyl-L-tryptophyl-L-leucyl-L-lysyl-L-asparaginylglycylglycyl-L-prolyl-L-seryl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-;LY2148568;AC-2993;CHEBI:64073;Exendin 3 (Heloderma horridum), 2-glycine-3-L-glutamic acid-;Exendin 4 (Heloderma suspectum);PT302;UNII-9P1872D4OL;A10BJ01;AC 2993A;AC-002993;AC-2993A;AC-2993LAR;AC2993;DA 3091;DA-3091;DTXCID001323055;DTXSID9040475;EXENATIDE (MART.);EXENATIDE (USP MONOGRAPH);EXENATIDE (USP-RS);HSDB 7789;ITCA-650;LY 2148568;LY-2148568;Synthetic exendin-4
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| M.F/Formula | C186H286N50O62S |
| Sequence | One Letter Code: HGEGXFXSDLSKQMEEEAVRLFXEWLKNGGPSSGAPPPS Three Letter Code: H-DL-His-Gly-DL-Glu-Gly-DL-xiThr-DL-Phe-DL-xiThr-DL-Ser-DL-Asp-DL-Leu-DL-Ser-DL-Lys-DL-Gln-DL-Met-DL-Glu-DL-Glu-DL-Glu-DL-Ala-DL-Val-DL-Arg-DL-Leu-DL-Phe-DL-xiIle-DL-Glu-DL-Trp-DL-Leu-DL-Lys-DL-Asn-Gly-Gly-DL-Pro-DL-Ser-DL-Ser-Gly-DL-Ala-DL-Pro-DL-Pro-DL-Pro-DL-Ser-NH2.CH3CO2H |
| Shipping Condition | Room temperature in continental US; may vary elsewhere. |
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