Peptide Vaccine Design
Vaccines are considered one of the most successful medical interventions in the past few centuries, aiming to harness the human immune system and generate lasting protection against specific diseases. Traditional vaccines …
Screening Strategies for Cyclopeptide Drugs
Cyclopeptides represent one of the most diverse architectures in current drug discovery efforts. Their small size, stability, and ease of synthesis provide an attractive scaffold for targeting and modulating some …
FDA Approved Peptide Drugs in the First Half of 2023
The FDA’s Center for Drug Evaluation and Research (CDER) regulatory approval of a total of 26 NME (New Molecular Entity) drugs in the first half of 2023. It is worth …
Classification of Impurities in Synthetic Peptide Drugs
Advantages of Peptides Peptides are a class of compounds formed by linking multiple amino acids through amide bonds, and their molecular size is between small molecule chemical drugs and macromolecular biological …
Analysis Methods for Peptide-Related Impurities in Peptide Drugs
Background Peptide drugs, as a type of pharmaceutical with molecular weight between small molecule chemical drugs and biopolymers, provide more options for medicinal chemists and have become a hot research …
Plant Protein-Derived Antioxidant Peptides: An Overview
Background In recent years, more and more studies have described the antioxidant capacity of plant protein-derived peptides. Plant proteins are considered a new source of antioxidant peptides that can not …
An Overview of Peptidomimetics-the Antiviral Drugs
Antiviral drugs Antiviral drugs are a class of drugs used to treat viral infections. While most antiviral drugs target specific viruses, broad-spectrum antivirals are effective against multiple viruses. Most of …
Peptides for Gastrointestinal Studies
The gastrointestinal tract is the largest immune organ in the human body. The gastrointestinal tract refers to the digestive tract from the gastric pylorus to the anus, including the stomach, …
Drug Development of Intranasally Delivered Peptides
Intranasal (IN, intranasal) delivery of peptides has received considerable attention as a potential non-invasive delivery route through which peptide drugs can easily enter systemic circulation. Nasal delivery offers several advantages, …
Methods to improve the metabolic stability of peptides
Given the rapid metabolism and short action time of peptide drugs, pharmaceutical chemists have explored a variety of methods to improve the metabolic stability of the peptide. The main recognition …