In recent years, anti-tumor peptides have emerged as a research hotspot in the biomedical field due to their unique molecular properties and broad therapeutic potential. Compared to traditional chemotherapy drugs, …
Peptides are functional nutrients that are the most active, easily absorbed, and capable of stimulating the body’s regeneration system, positioned between large protein molecules and small amino acids. They are …
Peptide synthesis, particularly solid-phase peptide synthesis (SPPS), is a widely employed method for creating peptides of varying lengths and sequences. The process has revolutionized the ability to produce synthetic peptides …
What is Trofinetide? Trofinetide is a synthetic glycine-proline-glutamic acid (GPE) tripeptide analogue derived from the N-terminal sequence of insulin-like growth factor 1 (IGF-1). It is primarily used to treat Rett …
As early as the 80s of the last century (1983), the exploration of oral delivery of peptides has achieved a historic breakthrough through cyclosporine A (Fig.1). This natural peptide can achieve …
Non-Ribosomal Peptide Synthetases (NRPSs) Non-ribosomal peptide synthesis is a universal and critical biochemical process catalyzed by NRPSs in bacteria and fungi, through which a wide array of therapeutically important peptides with …
In the field of weight loss drug development, the recently disclosed clinical data of Amgen’s weight loss candidate drug Maridebart Cafraglutide (referred to as MariTide, formerly known as AMG 133) …
Synthesis of peptides is a complex process that usually involves different synthesis strategies and techniques. The following are some common approaches to peptide synthesis processes and techniques: Solid-Phase Synthesis This is one …
Compared to linear peptides, cyclic peptides exhibit excellent biocompatibility and chemical diversity, making them effective in overcoming limitations and playing a crucial role in new drug development. In recent years, …
The formation of 2,5-diketopiperazine (DKP) with a bicyclic structure is one of the most detrimental side reactions and degradation pathways affecting peptide synthesis. Despite its crucial role as a versatile building block in drug …