What is Trofinetide? Trofinetide is a synthetic glycine-proline-glutamic acid (GPE) tripeptide analogue derived from the N-terminal sequence of insulin-like growth factor 1 (IGF-1). It is primarily used to treat Rett …
As early as the 80s of the last century (1983), the exploration of oral delivery of peptides has achieved a historic breakthrough through cyclosporine A (Fig.1). This natural peptide can achieve …
Non-Ribosomal Peptide Synthetases (NRPSs) Non-ribosomal peptide synthesis is a universal and critical biochemical process catalyzed by NRPSs in bacteria and fungi, through which a wide array of therapeutically important peptides with …
In the field of weight loss drug development, the recently disclosed clinical data of Amgen’s weight loss candidate drug Maridebart Cafraglutide (referred to as MariTide, formerly known as AMG 133) …
Synthesis of peptides is a complex process that usually involves different synthesis strategies and techniques. The following are some common approaches to peptide synthesis processes and techniques: Solid-Phase Synthesis This is one …
Compared to linear peptides, cyclic peptides exhibit excellent biocompatibility and chemical diversity, making them effective in overcoming limitations and playing a crucial role in new drug development. In recent years, …
The formation of 2,5-diketopiperazine (DKP) with a bicyclic structure is one of the most detrimental side reactions and degradation pathways affecting peptide synthesis. Despite its crucial role as a versatile building block in drug …
Vaccines are considered one of the most successful medical interventions in the past few centuries, aiming to harness the human immune system and generate lasting protection against specific diseases. Traditional vaccines …
Cyclopeptides represent one of the most diverse architectures in current drug discovery efforts. Their small size, stability, and ease of synthesis provide an attractive scaffold for targeting and modulating some …
The FDA’s Center for Drug Evaluation and Research (CDER) regulatory approval of a total of 26 NME (New Molecular Entity) drugs in the first half of 2023. It is worth …